Prevention or treatment: the benefits of Trichomonas vaginalis vaccine.
Prevention or treatment: the benefits of Trichomonas vaginalis vaccine.
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DOI：
10.1016/j.jiph.2010.01.003
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发表时间：
2010-01-01
影响因子：
6.7
通讯作者：
Garber, Gary E
中科院分区：
文献类型：
--
作者：
Cudmore, Sarah L;Garber, Gary E
滴虫病(感染阴道毛滴虫)是世界上最常见的非病毒性性传播疾病。虽然可以获得治疗，但大多数病例发生在发展中国家，那里很难获得医疗保健，设施有限。此外，感染通常是无症状的，因此得不到治疗，造成阴道毛滴虫的蓄水池，使疾病在社区内传播。正因为如此，在控制滴虫病发病率方面收效甚微，特别是在弱势群体中。开发一种针对阴道毛滴虫的疫苗可以减少与滴虫病相关的人力成本(怀孕并发症、不孕)、医疗成本(重复就诊、对人类免疫缺陷病毒(HIV)感染的易感性增加)和社会成本(性传播感染的耻辱、未经治疗的感染周期)。
Trichomoniasis (infection with Trichomonas vaginalis) is the most common non-viral sexually transmitted disease (STI) in the world. Although treatment is available, most cases occur in developing countries, where accessing healthcare is difficult and facilities are limited. Additionally, infection is often asymptomatic and as such goes untreated, creating reservoirs of T. vaginalis that allow the disease to spread within the community. Because of this there has been little success in controlling the incidence of trichomoniasis, especially amongst the underprivileged. The development of a vaccine against T. vaginalis could reduce the human costs (pregnancy complications, infertility), medical costs (repeated doctor visits, increased susceptibility to human immunodeficiency virus (HIV) infection), and societal costs (stigma of STI, cycles of untreated infection) associated with trichomoniasis.