Role of Apoptosis in Amplifying Inflammatory Responses in Lung Diseases.
Role of Apoptosis in Amplifying Inflammatory Responses in Lung Diseases.
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DOI：
10.4137/jcd.s5375
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发表时间：
2010-07-20
期刊：
影响因子：
--
通讯作者：
Tuder RM
中科院分区：
文献类型：
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作者：
Schmidt EP;Tuder RM
细胞凋亡是肺疾病如急性肺损伤（ALI）和慢性阻塞性肺疾病（COPD）的病理生理学的重要贡献者。此外，这些急性和慢性肺部疾病的细胞环境有利于凋亡细胞的延迟清除。这种功能障碍性红细胞增多症倾向于从垂死细胞释放内源性配体。这些所谓的损伤相关分子模式（DAMP）在刺激先天免疫以及诱导适应性免疫（可能针对自身抗原）中发挥重要作用。在这篇综述中，我们探讨了细胞凋亡在ALI和COPD中的作用，特别关注DAMP释放在这些疾病状态下增加炎症反应的贡献。
Apoptosis is an important contributor to the pathophysiology of lung diseases such as acute lung injury (ALI) and chronic obstructive pulmonary disease (COPD). Furthermore, the cellular environment of these acute and chronic lung diseases favors the delayed clearance of apoptotic cells. This dysfunctional efferocytosis predisposes to the release of endogenous ligands from dying cells. These so-called damage-associated molecular patterns (DAMPs) play an important role in the stimulation of innate immunity as well as in the induction of adaptive immunity, potentially against autoantigens. In this review, we explore the role of apoptosis in ALI and COPD, with particular attention to the contribution of DAMP release in augmenting the inflammatory response in these disease states.