Interactive effects of MK-801 and morphine on EEG, EEG power spectra and behavior in rats: I. Morphine tolerance development.
Interactive effects of MK-801 and morphine on EEG, EEG power spectra and behavior in rats: I. Morphine tolerance development.
复制标题
MK-801 和吗啡对大鼠脑电图、脑电图功率谱和行为的相互作用影响：I. 吗啡耐受性发展。
DOI：
10.1016/0014-2999(94)90293-3
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发表时间：
1994
影响因子：
5
通讯作者：
Young,GA
中科院分区：
文献类型：
--
作者：
Haberny,KA;Young,GA
本研究采用大鼠脑电图（EEG）、EEG频谱参数和行为学研究MK-801与吗啡耐受之间的潜在相互作用。大鼠接受吗啡单独给药或吗啡和MK-801联合给药7天。对照组接受长期单独MK-801或生理盐水。在第8天，所有大鼠仅接受吗啡。共同治疗显着加速发展的耐受性吗啡诱导的总功率和潜伏期的睡眠开始。共同治疗，但不是吗啡单独，产生耐受吗啡诱导的复杂性和边缘频率，并产生耐受性等于从吗啡单独的持续时间的EEG爆发。MK-801联合给药降低了对吗啡的兴奋性反应，而慢性吗啡单独给药增加了对吗啡的兴奋性反应。我们的研究结果支持最近的报告，慢性吗啡治疗产生超敏谷氨酸在大鼠皮层和中脑边缘多巴胺水平的变化，是由多巴胺能活动调制。
This study investigated a potential interaction between MK-801 and morphine tolerance using electroencephalography (EEG), EEG spectral parameters and behavior in the rat. Rats were treated for 7 days with morphine alone or with morphine and MK-801. Control groups receive chronic MK-801 alone or saline. On day 8 all rats received morphine alone. Co-treatment significantly accelerated the development of tolerance to morphine-induced total power and latency to sleep onset. Co-treatment, but not morphine alone, produced tolerance to morphine-induced complexity and edge frequency, and produced tolerance equal to that from morphine alone in duration of EEG bursting. MK-801 co-treatment decreased, where chronic morphine alone increased, the excitatory response to morphine. Our results support recent reports that chronic morphine treatment produces supersensitivity to glutamate in the rat cortex and alteration in mesolimbic dopamine levels that are modulated by glutamatergic activity.