Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.
Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.
复制标题
将酒精性肝病的致病机制与临床表型联系起来。
DOI：
10.1053/j.gastro.2016.02.035
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发表时间：
2016-06
期刊：
影响因子：
29.4
通讯作者：
Shah VH
中科院分区：
文献类型：
--
作者：
Nagy LE;Ding WX;Cresci G;Saikia P;Shah VH
酒精性肝病（ALD）在大约20%的酗酒者中发展，女性患病率更高。ALD的进展表现为脂肪肝和肝细胞坏死，以及细胞凋亡、炎症、再生结节、纤维化和肝硬化。ALD的发展是一个复杂的过程，涉及实质细胞和非实质细胞，以及其他类型的细胞在肝脏损伤和炎症反应中的募集。乙醇通过产生活性氧和诱导内质网应激和线粒体功能障碍对肝细胞造成损伤。肝细胞凋亡和坏死是乙醇性肝损伤的标志。本文综述了酒精损伤肝细胞的机制以及肝窦细胞对酒精损伤的反应。我们还讨论了最近对ALD发病机制的见解将如何影响患者的治疗和管理。
Alcoholic liver disease (ALD) develops in approximately 20% of alcoholics, with a higher prevalence in females. ALD progression is marked by fatty liver and hepatocyte necrosis, as well as apoptosis, inflammation, regenerating nodules, fibrosis, and cirrhosis . ALD develops via a complex process involving parenchymal and non-parenchymal cells, as well as recruitment of other cell types to the liver in response to damage and inflammation. Hepatocytes are damaged by ethanol, via generation of reactive oxygen species and induction of endoplasmic reticulum stress and mitochondrial dysfunction. Hepatocyte cell death via apoptosis and necrosis are markers of ethanol-induced liver injury. We review the mechanisms by which alcohol injures hepatocytes and the response of hepatic sinusoidal cells to alcohol-induced injury. We also discuss how recent insights into the pathogenesis of ALD will affect treatment and management of patients.