Prognostic value of tropomyosin-related kinases A, B, and C in gastric cancer
Prognostic value of tropomyosin-related kinases A, B, and C in gastric cancer
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DOI：
10.1007/s12094-015-1407-7
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发表时间：
2016-06-01
影响因子：
3.4
通讯作者：
Kojima, K.
中科院分区：
文献类型：
--
作者：
Kamiya, A.;Inokuchi, M.;Kojima, K.
原肌球蛋白相关激酶（Trk）受体在肿瘤发生发展中起着关键作用，被认为是肿瘤治疗的有吸引力的靶点。我们研究了TrkA、TrkB和TrkC的表达与胃癌临床病理特征和预后的相关性，肿瘤样本来自2003年至2007年间接受胃切除术的221例胃癌患者。采用免疫组化法检测TrkA、TrkB和TrkC的表达。TrkA、TrkB或TrkC的高表达与组织病理学显著相关（p = 0.022，p < 0.001，p < 0.001）。TrkA的高表达与肿瘤进展相关的变量显著相关，包括淋巴结转移（p = 0.024）和远处转移或复发（p < 0.001）。发现远处转移或复发的患者中高表达TrkC的比例显著高于低表达的患者（p = 0.036）。在单变量分析中，TrkA的高表达与较差的无复发生存期（RFS）显著相关（p = 0.001）。在单变量分析中，TrkA或TrkC的高表达与较差的疾病特异性存活（DSS）显著相关（p < 0.001和p = 0.008）。在多变量分析中，TrkA是RFS [风险比（HR），2.294; 95%置信区间（CI），1.309-4.032; p = 0.004]和DSS（HR，2.146; 95% CI，1.195-3.861; p = 0.011）的独立预测因子。单因素分析显示TrkB的表达与RFS和DSS无关，而TrkA的表达与胃癌患者的肿瘤进展和不良生存率相关，是胃癌患者不良预后的独立预测因子。
Tropomyosin-related kinase (Trk) receptors play critical roles in tumor development and are considered attractive targets for cancer therapy. We investigated correlations of the expression of TrkA, TrkB, and TrkC with clinicopathological features and outcomes in gastric cancer.Tumor samples were obtained from 221 patients with gastric cancer who underwent gastrectomy between 2003 and 2007. The expression of TrkA, TrkB, and TrkC was analyzed using immunohistochemical staining. The relationship of their expression to clinicopathological factors and outcomes was assessed.High expression of TrkA, TrkB, or TrkC was significantly associated with histopathology (p = 0.022, p < 0.001, and p < 0.001). High expression of TrkA was significantly correlated with variables related to tumor progression, including lymph node metastasis (p = 0.024) and distant metastasis or recurrence (p < 0.001). Distant metastasis or recurrence was found in a significantly higher proportion of patients with high expression of TrkC than in those with low expression (p = 0.036). High expression of TrkA was significantly associated with poorer relapse-free survival (RFS) in univariate analysis (p = 0.001). High expression of TrkA or TrkC was significantly associated with poorer disease-specific survival (DSS) in univariate analysis (p < 0.001 and p = 0.008). In multivariate analysis, TrkA was an independent predictor of RFS [hazard ratio (HR), 2.294; 95 % confidence interval (CI), 1.309-4.032; p = 0.004] and DSS (HR, 2.146; 95 % CI, 1.195-3.861; p = 0.011). Expression of TrkB was not associated with RFS or DSS in univariate analysis.Our results demonstrated that TrkA expression was associated with tumor progression and poor survival, and was an independent predictor of poor outcomes in gastric cancer patients.