Altered biodistribution of FDG in patients with type-2 diabetes mellitus
Altered biodistribution of FDG in patients with type-2 diabetes mellitus
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DOI：
10.1007/s12149-014-0840-y
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发表时间：
2014-07-01
影响因子：
2.6
通讯作者：
Emer, Mustafa O.
中科院分区：
文献类型：
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作者：
Ozguven, Mehmet A.;Karacalioglu, Alper O.;Emer, Mustafa O.
糖尿病患者的正电子发射断层扫描-计算机断层扫描 (PET-CT) 成像可能存在问题，因为血糖水平升高可能会导致不同组织中 [F-18]-2-脱氧-2-氟-d-葡萄糖 (FDG) 摄取的竞争性抑制。因此，本研究的目的是评估 2 型糖尿病患者中 FDG 的生物分布。回顾性纳入该研究的 240 名患者。研究人群分为三个亚组，分别为正常组（第1组）、胰岛素组（第2组）和口服降糖药组（第3组）。从大腿中部到头骨顶点获取未增强的低剂量 CT 和 PET 发射数据。对不同器官的FDG摄取进行定性或半定量评估。在糖尿病组中，结肠的弥漫性FDG摄取增加（p>0.001），但节段性FDG摄取减少（p>0.001）。 20% 的研究人群检测到肠道 FDG 摄取，其中只有 3% 的摄取呈弥散型。糖尿病患者组中肠道的节段 FDG 摄取显着增加 (p = 0.002)。第1组、第2组和第3组的肝脏最大标准化摄取值分别为2.66+/-A 0.6、3.25+/-A 0.9和3.16+/-A 0.8，组间差异无统计学意义（p = 0.083）。糖尿病患者组中心脏 FDG 摄取量显着下降 (p < 0.001)。根据我们的结果，使用胰岛素或口服降糖药的 2 型糖尿病患者中 FDG 摄取的全身生物分布似乎发生了变化。尽管已知口服抗糖尿病药物的使用会改变 FDG 的生物分布，但胰岛素的使用似乎也会改变糖尿病患者不同器官中 FDG 的摄取。
Positron emission tomography-computed tomography (PET-CT) imaging of patients with diabetes can be problematic because elevated glucose levels may cause competitive inhibition of [F-18]-2-deoxy-2-fluoro-d-glucose (FDG) uptake in different tissues. Therefore, the aim of the study was to evaluate the biodistribution of FDG in patients with type-2 diabetes mellitus.Two hundred forty patients were retrospectively enrolled to the study. Study population was divided into three subgroups, named as the normal (group 1), the insulin (group 2) and the oral anti-diabetic (group 3). Unenhanced low-dose CT and PET emission data were acquired from the mid-thigh to the vertex of the skull. FDG uptakes in different organs were evaluated qualitatively or semi-quantitatively.In the diabetic groups, diffuse FDG uptake of the colon was increased (p > 0.001) but segmental FDG uptake was decreased (p > 0.001). Intestinal FDG uptake was detected in 20 % of the study population and only 3 % of these uptakes were in diffuse pattern. Segmental FDG uptake in the bowel was increased significantly in the groups of patients with diabetes (p = 0.002). Maximum standardized uptake values of the liver in the groups 1, 2, and 3 were 2.66 +/- A 0.6, 3.25 +/- A 0.9 and 3.16 +/- A 0.8, respectively, and the difference between the groups was not statistically significant (p = 0.083). Cardiac FDG uptake was decreased significantly in the groups of patients with diabetes (p < 0.001).According to our results, whole body biodistribution of FDG uptake seems to be changed in patients with type-2 diabetes who were using insulin or oral antidiabetic drugs. Although the use of oral antidiabetic drugs was known to change the biodistribution of FDG, insulin use also seems to change FDG uptake in different organs of diabetic patients.