Reduction of trace but not delay eyeblink conditioning in panic disorder
Reduction of trace but not delay eyeblink conditioning in panic disorder
复制标题
DOI：
10.1176/appi.ajp.164.2.283
复制
发表时间：
2007-02-01
影响因子：
17.7
通讯作者：
Pine, Daniel S.
中科院分区：
文献类型：
--
作者：
Grillon, Christian;Lissek, Shmuel;Pine, Daniel S.
目的：惊恐障碍患者认为惊恐发作是不可预测的。因为可预测性是巴甫洛夫条件反射的基础，所以无法预测恐慌发作可能是由于条件反射的基本缺陷。本研究探讨跟踪眨眼条件，以测试的假设，个人与恐慌症受损的联想学习任务，依赖于statementary memory.Method：延迟和跟踪眨眼条件进行了测试，在单独的实验会议在19个人符合DSM-IV标准的恐慌症和19个性别和年龄匹配的健康对照组。在延迟模式中，在500毫秒的音调结束时向眼睛发出轻微的抽吸;在跟踪模式中，在音调结束后的700毫秒空"跟踪"间隔后发出抽吸。结果：患者和对照受试者在延迟模式中显示出相似的条件反射率，但患者在跟踪模式中显示出降低的条件反射率。这些结果表明，惊恐障碍患者在陈述性联想学习方面存在缺陷。这种缺陷表明海马体功能受损，可能会破坏预测恐慌发作的内部和外部线索的认知处理。
Objective: Individuals with panic disorder perceive panic attacks as unpredictable. Because predictability is fundamental to Pavlovian conditioning, failure to predict panic attacks could be due to a basic deficit in conditioning. The present study examined trace eyeblink conditioning in order to test the hypothesis that individuals with panic disorder are impaired in associative learning tasks that depend on declarative memory.Method: Delay and trace eyeblink conditioning were tested in separate experimental sessions in 19 individuals meeting DSM-IV criteria for panic disorder and 19 sex- and age-matched healthy comparison subjects. In the delay paradigm, a mild puff was delivered to the eye at the end of a 500-msec tone; in the trace paradigm, the puff was delivered after a 700-msec empty "trace" interval that followed the end of the tone.Results: Patients and comparison subjects showed similar rates of conditioned responses in the delay paradigm, but patients showed reduced rates of conditioned responses in the trace paradigm.Conclusions: These results suggest that individuals with panic disorder suffer from a deficit in declarative associative learning. Such a deficit points to impaired hippocampal function that may disrupt cognitive processing of internal and external cues predictive of a panic attack.