The potential of human milk oligosaccharides to impact the microbiota-gut-brain axis through modulation of the gut microbiota
The potential of human milk oligosaccharides to impact the microbiota-gut-brain axis through modulation of the gut microbiota
复制标题
人乳低聚糖通过调节肠道微生物区系影响微生物区系-肠道-脑轴的潜力
DOI：
10.1016/j.jff.2020.104176
复制
发表时间：
2020-11-01
影响因子：
5.6
通讯作者：
Vigsnaes, Louise Kristine
中科院分区：
文献类型：
--
作者：
Al-Khafaji, Alia H.;Jepsen, Stine Dam;Vigsnaes, Louise Kristine
人乳低聚糖（HMO）是人类在生活中遇到的第一种益生元。HMO对婴儿有许多益处，包括影响肠道细菌，促进出生后大脑发育和调节免疫系统。一个称为微生物-肠道-大脑轴的复杂双向通信途径将肠道稳态和微生物组成与中枢神经系统（CNS）联系起来。已知由肠道微生物群调节的几种机制会影响该轴。微生物群组成的动态改变了肠道中的代谢产物，包括影响大脑功能和健康的神经活性生物分子。肠道菌群也有可能影响和相互作用的神经，免疫和内分泌途径的微生物-肠-脑axill.In这篇综述中，我们讨论了HMO的潜在作用，在微生物-肠-脑轴和中枢神经系统疾病，通过描述的作用，肠道菌群与大脑健康和饮食干预的重要性，在操纵微生物-肠-脑轴。
Human milk oligosaccharides (HMOs) are the first prebiotics humans meet in life. HMOs provide many benefits to infants including impact on gut bacteria, promotion of postnatal brain development, and modulation of the immune system.A complex bidirectional communication pathway called the microbiota-gut-brain axis links gut homeostasis and microbial composition with the central nervous system (CNS). Several mechanisms regulated by the gut microbiota are known to affect this axis. Dynamics in microbiota composition changes the metabolite profile in the gut, including neuroactive biomolecules that influence brain function and health. The gut microbiota also has the potential to affect and interact with the neurologic, immunologic and endocrine pathways of the microbiota-gut-brain axis.In this review, we discuss the potential role of HMOs in microbiota-gut-brain axis and CNS disorders, by describing the role of the gut microbiota in relation to brain health and the importance of dietary interventions in manipulating the microbiota-gut-brain axis.