Genetic control of epithelial cell polarity: Lessons from Drosophila
Genetic control of epithelial cell polarity: Lessons from Drosophila
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DOI：
10.1002/(sici)1097-0177(200005)218:1
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发表时间：
2000-05
影响因子：
2.5
通讯作者：
Hj. Müller
中科院分区：
文献类型：
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作者：
Hj. Müller
极化上皮细胞的细胞生物学是细胞和发育生物学家感兴趣的主要领域。除了组织培养中上皮细胞的研究外，遗传可处理系统已被用于检查单个分子的功能重要性。在这里，我回顾了最近使用果蝇作为模型系统来研究顶端-基底上皮细胞极性的进展。在这个系统中，已经发现了大量基因，这些基因对不同发育背景下上皮细胞的顶基极性的发育和维持至关重要。本文将讨论胚胎发生过程中外胚层和中肠上皮的建立、影像盘上皮极性和卵泡细胞在卵发生过程中的上皮发育这三种模型的最新进展。Dev动力学;218:52 - 67。©2000 Wiley‐Liss, Inc。
The cell biology of polarized epithelial cells is a field of major interest to cell and developmental biologists. In addition to the study of epithelial cells in tissue culture, genetically tractable systems have been employed to examine the functional importance of individual molecules. Here I review recent progress that has been made using Drosophila as a model system to study apical‐basal epithelial cell polarity. In this system, a large number of genes have been identified that are essential for the development and maintenance of the apical‐basal polarity of epithelial cells in different developmental contexts. In this article, the recent progress in three models, i.e., establishment of the ectoderm and midgut epithelia during embryogenesis, epithelial polarity of imaginal discs, and epithelial development of the follicle cells during oogenesis will be discussed. Dev Dyn;218:52–67. © 2000 Wiley‐Liss, Inc.