Glucose metabolism measured by positron emission tomography is reduced in patients with white matter presumably ischemic lesions.
Glucose metabolism measured by positron emission tomography is reduced in patients with white matter presumably ischemic lesions.
复制标题
通过正电子发射断层扫描测量的白质疑似缺血性病变患者的葡萄糖代谢减少
DOI：
10.12659/msm.892137
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发表时间：
2014-08-27
期刊：
影响因子：
--
通讯作者：
Hu W
中科院分区：
文献类型：
--
作者：
Li J;Hu W
背景白质缺血性病变（WMIL）的严重程度和进展与血管性痴呆密切相关。神经组织的功能与葡萄糖消耗密切相关，葡萄糖是最重要的供能代谢过程。目前，18氟氟脱氧葡萄糖（18FDG）正电子发射断层扫描（PET）可以提供人脑葡萄糖代谢的区域和3维定量。尽管 MMSE 和 MoCA 是认知障碍中常用的筛查方法，但尚未有研究团队验证它们在 WMIL 中的表现。我们研究的目的是比较 MMSE 和 MoCA 在认知障碍筛查中的作用，并探讨 CMRglu 值与执行功能之间的相关性。材料/方法 所有参与者均接受了全面的临床、MoCA、MMSE、MRI 和 PET 检查。根据 Fazekas 量表，WMIL 组患者被分为 3 个严重程度亚组。结果 WMIL 组 MoCA 评分较低。我们的研究表明，在检测 WMIL 患者的认知障碍方面，MoCA 是比常用的 MMSE 更灵敏的筛查工具。 WMIL 组灰质的 CMRglu 值降低。根据改良的 Fazekas 量表，在 WMIL 组中观察到顶叶、额叶和半卵圆白质中心的 CMRglu 有不同程度的降低。额叶执行功能与 CMRglu 之间存在显着负相关。结论 在检测 WMIL 患者的认知障碍方面，MoCA 似乎是比常用的 MMSE 更敏感的筛查工具。 CMRglu 有可能用作预测 WMIL 严重程度的生物标志物。
Background The severity and progression of white matter ischemic lesion (WMIL) are closely linked to vascular dementia. The function of neural tissue is closely linked to glucose consumption as the most important energy-supplying metabolic process. At present, 18fluorine-fluorodeoxy glucose (18FDG) positron emission tomography (PET) can provide regional and 3-dimensional quantification of glucose metabolism in the human brain. Although MMSE and MoCA are commonly used screens in cognitive impairment, no research team has yet validated their performance in WMIL. The purpose of our study was to compare MMSE and MoCA in screening for cognitive impairment and to explore the correlations between CMRglu values and executive function. Material/Methods All the participants underwent comprehensive clinical, MoCA, MMSE, MRI, and PET examinations. Patients in the WMIL group were subdivided into 3 severity subgroups according to the Fazekas scale. Results The MoCA scores were lower in the WMIL group. Our research indicates that MoCA is a more sensitive screening tool than the commonly used MMSE in detecting cognitive impairment in patients with WMIL. CMRglu values of gray matter were decreased in the WMIL group. Reductions of CMRglu in parietal lobe, frontal lobe, and white matter centrum semiovale were observed to different degrees in the WMIL groups according to the modified Fazekas scale. A significant negative correlation was found between executive function and CMRglu in the frontal lobe. Conclusions MoCA appears to be a more sensitive screening tool than the commonly used MMSE in detecting cognitive impairment in patients with WMIL. CMRglu can potentially be used as a biomarker for predicting the severity of WMIL.