The effect of progesterone and pregnenolone on diabetes status in Chinese rural population: a dose-response analysis from Henan Rural Cohort
The effect of progesterone and pregnenolone on diabetes status in Chinese rural population: a dose-response analysis from Henan Rural Cohort
复制标题
黄体酮和孕烯醇酮对中国农村人口糖尿病状况的影响：来自河南农村队列的剂量反应分析
DOI：
10.1530/eje-19-0352
复制
发表时间：
2019-12-01
影响因子：
5.8
通讯作者：
Mao, Zhenxing
中科院分区：
文献类型：
--
作者：
Jiang, Jingjing;Liu, Xue;Mao, Zhenxing
目的：以前的研究已经发现，仅服用孕激素避孕药会增加患糖尿病的风险，但探讨内源性孕酮和孕烯醇酮水平与糖尿病状态的关系的研究有限。设计：病例对照研究。方法：纳入798例T2 DM患者、779例糖尿病前期患者和782例空腹血糖正常者。血清孕酮、孕烯醇酮采用高效液相色谱-串联质谱仪进行检测。用Logistic回归和限制三次样条法评价孕酮和孕烯醇酮对糖尿病前期和T2 DM的独立作用。结果：孕酮四分位数与糖尿病前期(优势比(OR)(95%CI)：2.66(1.99~3.55))和2型糖尿病(OR(95%CI)：6.41(4.57~8.98))呈正相关，而孕烯醇酮与糖尿病前期(OR(95%CI)：0.23(0.16~0.33))和T2 DM(OR(95%CI)：0.44(0.31~0.62))呈负相关。此外，还发现孕酮和孕烯醇酮与糖尿病前期和T2 DM之间存在非线性剂量-反应关系。黄体酮和孕烯醇酮对糖尿病前期和T2 DM的交互作用在性别分层分析中仍然存在。结论：在中国农村人群中，糖尿病前期和T2 DM与血清孕酮浓度呈正相关，与孕烯醇酮呈剂量-反应负相关。
Objective: Previous studies have uncovered a progestin-only contraceptive association with an increased risk of diabetes, but limited studies have explored the relationship of endogenous progesterone and pregnenolone levels with diabetes status. A case-control study was conducted in Henan Rural Cohort (register number: ChiCTR-OOC-15006699) to evaluate the dose-response independent and interactive relationship of progesterone and pregnenolone levels with prediabetes and type 2 diabetes mellitus (T2DM) in Chinese rural population.Design: A case-control study.Methods: A total of 798 T2DM patients, 779 prediabetes patients, and 78 2 individuals with normal fasting plasma glucose were included in this study. Serum progesterone and pregnenolone were detected by liquid chromatography-tandem mass spectrometry. Logistic regression and restricted cubic splines were used to assess the independent effects of progesterone and pregnenolone on prediabetes and T2DM. Interactive plots were employed to examine the interaction effects of progesterone and pregnenolone.Results: Progesterone in the fourth versus first quartile was positively associated with prediabetes (odds ratio (OR) (95% CI): 2.66 (1.99-3.55)) and T2DM (OR (95% CI): 6.41 (4.57-8.98)), whereas pregnenolone in the fourth versus first quartile was inversely related to prediabetes (OR (95% CI): 0.23 (0.16-0.33)) and T2DM (OR (95% CI): 0.44 (0.31-0.62)). Additionally, the nonlinear dose-response associations between progesterone and pregnenolone with prediabetes and T2DM were found. Interactive effects of progesterone and pregnenolone on prediabetes and T2DM were observed, and these significant associations remained in gender-stratified analysis.Conclusions: Prediabetes and T2DM were positively linked to serum concentration of progesterone and negatively related to pregnenolone in a dose-response manner in Chinese rural population.