Association of lincRNA-p21 Haplotype with Coronary Artery Disease in a Chinese Han Population.
Association of lincRNA-p21 Haplotype with Coronary Artery Disease in a Chinese Han Population.
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DOI：
10.1155/2016/9109743
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Xiong XD
中科院分区：
文献类型：
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作者：
Tang SS;Cheng J;Cai MY;Yang XL;Liu XG;Zheng BY;Xiong XD
lincRNA-p21在冠心病（coronary artery disease，CAD）的发病和进展中起重要作用。到目前为止，lincRNA-p21多态性对CAD风险的生物学意义仍然未知。本研究旨在评估lincRNA-p21多态性对个体CAD易感性的影响。对615例CAD患者和655例对照者进行lincRNA-p21基因内4个tagSNPs（rs 9380586、rs 4713998、rs6930083和rs6931097）的基因分型。单倍型分析显示，单倍型G-A-A-G（rs 9380586-rs 4713998-rs6930083-rs6931097）与冠心病发病风险降低有统计学意义（OR = 0.78，P = 0.023）。分层分析显示G-A-A-G单倍型与心肌梗死（MI）的危险性显著降低（OR = 0.68，P = 0.010）。我们还发现单倍型G-A-A-G具有更显著的早发CAD或MI受试者的风险降低（早发CAD的OR = 0.67，P = 0.017;早发MI的OR = 0.65，P = 0.041）。我们的数据首次证明lincRNA-p21的G-A-A-G单倍型与CAD和MI的风险降低相关，特别是在中国汉族人群中的早发CAD/MI。进一步的研究，更多的主题和不同的种族人群是必要的，以澄清我们的研究结果的一般有效性。
lincRNA-p21 plays an important role in the pathogenesis and progression of coronary artery disease (CAD). To date, the biological significance of polymorphisms in lincRNA-p21 on CAD risk remains unknown. Here we aimed to evaluate the influence of lincRNA-p21 polymorphisms on individual susceptibility to CAD. Genotyping of four tagSNPs (rs9380586, rs4713998, rs6930083, and rs6931097) within lincRNA-p21 gene was performed in 615 CAD and 655 controls. The haplotype analysis showed that the haplotype G-A-A-G (rs9380586-rs4713998-rs6930083-rs6931097) was statistically significantly associated with the reduced risk for CAD (OR = 0.78, P = 0.023). Stratified analysis revealed that G-A-A-G haplotype was at a significantly lower risk for myocardial infarction (MI) (OR = 0.68, P = 0.010). We also found that haplotype G-A-A-G had a more pronounced decreased risk for premature CAD or MI subjects (OR = 0.67, P = 0.017 for premature CAD, and OR = 0.65, P = 0.041 for premature MI, resp.). Our data provide the first evidence that the G-A-A-G haplotype of lincRNA-p21 is associated with decreased risk of CAD and MI, particularly among premature CAD/MI in the Chinese Han population. Further studies with more subjects and in diverse ethnic populations are warranted to clarify the general validity of our findings.