The extracellular matrix as a biologic scaffold material
The extracellular matrix as a biologic scaffold material
复制标题
DOI：
10.1016/j.biomaterials.2007.04.043
复制
发表时间：
2007-09-01
期刊：
影响因子：
14
通讯作者：
Badylak, Stephen F.
中科院分区：
文献类型：
--
作者：
Badylak, Stephen F.
由细胞外基质（ECM）组成的生物支架因其潜在的治疗应用而受到广泛关注。然而，在更好地了解生物学和影响生物学的外部影响之前，ECM支架促进建设性重塑的能力的全部潜力将不会被实现。对于ECM生物支架的建设性重塑来说，重要的因素是其快速和完全降解下游生物活性分子的能力，组成天然ECM材料的功能分子的生物诱导特性，以及通过了解其胶原纤维微观结构在植入时设计其机械特性的能力。(c) 2007年Elsevier Ltd.出版
Biologic scaffolds composed of naturally occurring extracellular matrix (ECM) have received significant attention for their potential therapeutic applications. The full potential of the ability of ECM scaffolds to promote constructive remodeling will not be realized, however, until an understanding of the biology and the external influences that affect biology, are better achieved. The factors that appear important for the constructive remodeling of ECM biologic scaffolds are its ability to be rapidly and completely degraded with the generation of downstream bioactive molecules, the bioinductive properties of the functional molecules that compose native ECM material and the ability to engineer its mechanical properties at the time of implantation through an understanding of its collagen fiber microstructure. (c) 2007 Published by Elsevier Ltd.