Signaling-Mediated Regulation of Meiotic Prophase I and Transition During Oogenesis.
Signaling-Mediated Regulation of Meiotic Prophase I and Transition During Oogenesis.
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DOI：
10.1007/978-3-319-44820-6_4
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发表时间：
2017
影响因子：
--
通讯作者：
Arur S
中科院分区：
文献类型：
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作者：
Arur S
健康卵母细胞的产生需要多种细胞事件和信号通路的协调调节。卵母细胞经历独特的发育生长和分化模式，其间穿插着长时间的停滞。几乎所有物种的卵母细胞都停滞在卵子发生的前期 I，这允许正常卵母细胞发育所必需的长期生长和分化。根据物种的不同，从前期 I 过渡到减数分裂 I 的卵母细胞也会在减数分裂 I 处停滞相当长的一段时间，然后在受精时完成的减数分裂 II 处进行第二次停滞。虽然线虫、黑腹果蝇和哺乳动物卵母细胞在前期 I、减数分裂 I 或减数分裂 II 停滞阶段存在物种特异性差异，但在所有情况下，细胞信号传导途径都协调控制卵母细胞生长和分化的发育事件，以调节这些关键的过渡阶段。特别是，ERK MAP 激酶信号通路、环化 AMP 第二信使和细胞周期调节因子 CDK1/细胞周期蛋白 B 是关键信号通路，它们在控制跨物种卵母细胞生长和减数分裂成熟方面似乎在进化上是保守的。在这里，我确定了卵母细胞生长和成熟过程中关键减数分裂事件调节的共同主题和差异。
Generation of healthy oocytes requires coordinated regulation of multiple cellular events and signaling pathways. Oocytes undergo a unique developmental growth and differentiation pattern interspersed with long periods of arrest. Oocytes from almost all species arrest in prophase I of oogenesis that allows for long period of growth and differentiation essential for normal oocyte development. Depending on species, oocytes that transit from prophase I to meiosis I also arrest at meiosis I for fairly long periods of time and then undergo a second arrest at meiosis II that is completed upon fertilization. While there are species-specific differences in C. elegans, D. melanogaster, and mammalian oocytes in stages of prophase I, meiosis I, or meiosis II arrest, in all cases cell signaling pathways coordinate the developmental events controlling oocyte growth and differentiation to regulate these crucial phases of transition. In particular, the ERK MAP kinase signaling pathway, cyclic AMP second messengers, and the cell cycle regulators CDK1/cyclin B are key signaling pathways that seem evolutionarily conserved in their control of oocyte growth and meiotic maturation across species. Here, I identify the common themes and differences in the regulation of key meiotic events during oocyte growth and maturation.