T Cell Fates Zipped Up: How the Bach2 Basic Leucine Zipper Transcriptional Repressor Directs T Cell Differentiation and Function.
T Cell Fates Zipped Up: How the Bach2 Basic Leucine Zipper Transcriptional Repressor Directs T Cell Differentiation and Function.
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DOI：
10.4049/jimmunol.1600847
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发表时间：
2016-08-15
期刊：
影响因子：
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通讯作者：
Butler NS
中科院分区：
文献类型：
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作者：
Richer MJ;Lang ML;Butler NS
最近的数据表明转录调节因子 Bach2 在协调 T 细胞分化和功能中发挥着关键作用。尽管 Bach2 在 B 细胞分化中的作用已得到充分描述，但新出现的数据表明，Bach2 是一类新型转录因子的典型成员，可调节 T 细胞超级增强子或高转录活性区域的转录活性。积累的数据表明 Bach2 在促进调节性 T 细胞生成、抑制效应 T 细胞分化和增强记忆 T 细胞发育方面具有特定作用。有证据表明，Bach2 通过抑制其他关键转录调节因子（例如 Blimp-1）来调节 T 细胞功能的各个方面。这篇综述探讨了我们目前对 Bach2 在 T 细胞功能中的作用的理解，并强调了越来越多的证据表明，这种转录阻遏蛋白作为关键调节因子参与维持 T 细胞静止、T 细胞亚群分化和记忆 T 细胞生成。
Recent data illustrate a key role for the transcriptional regulator Bach2 in orchestrating T cell differentiation and function. Although Bach2 has a well-described role in B cell differentiation, emerging data show that Bach2 is a prototypical member of a novel class of transcription factors that regulates transcriptional activity in T cells at super enhancers, or regions of high transcriptional activity. Accumulating data demonstrate specific roles for Bach2 in favoring regulatory T cell generation, restraining effector T cell differentiation and potentiating memory T cell development. Evidence suggests that Bach2 regulates various facets of T cell function by repressing other key transcriptional regulator such as Blimp-1. This review examines our current understanding of the role of Bach2 in T cell function and highlights the growing evidence that this transcriptional repressor functions as a key regulator involved in maintenance of T cell quiescence, T cell subset differentiation and memory T cell generation.