TRANSLOCATION OF THE C-MYC GENE INTO THE IMMUNOGLOBULIN HEAVY-CHAIN LOCUS IN HUMAN BURKITT-LYMPHOMA AND MURINE PLASMACYTOMA CELLS
TRANSLOCATION OF THE C-MYC GENE INTO THE IMMUNOGLOBULIN HEAVY-CHAIN LOCUS IN HUMAN BURKITT-LYMPHOMA AND MURINE PLASMACYTOMA CELLS
复制标题
DOI：
10.1073/pnas.79.24.7837
复制
发表时间：
1982-01-01
期刊：
影响因子：
--
通讯作者：
LEDER, P
中科院分区：
文献类型：
--
作者：
TAUB, R;KIRSCH, I;LEDER, P
人类伯基特淋巴瘤和小鼠浆细胞瘤中特异性染色体易位的一致出现表明这些易位可能在恶性转化中起作用。本文表明，这些细胞的转化经常伴随着禽逆转录病毒转化基因c-myc的细胞类似物的体细胞重排。c-myc定位于人8号染色体q24带，该染色体片段涉及相互Burkitt易位[t（8;14），t（8;22）和t（2;8）]。在2 t（8;14）人Burkitt细胞系中，c-myc似乎已直接易位到也编码IG μ的DNA限制性片段中。链基因在来源于小鼠浆细胞瘤的DNA的特异性克隆片段中，c-myc已经易位到IG α中。开关区域。这些数据为考虑特定易位在恶性转化中可能发挥的作用提供了分子基础。
The consistent appearance of specific chromosomal translocations in human Burkitt lymphomas and murine plasmacytomas has suggested that these translocations might play a role in malignant transformation. This paper shows that transformatin of these cells is frequently accompanied by the somatic rearrangement of a cellular analog of an avian retrovirus transforming gene, c-myc. c-myc was mapped to human chromosome 8 band q24, the chromosomal segment involved in the reciprocal Burkitt translocations [t(8;14), t(8;22) and t(2;8)]. In 2 t(8;14) human Burkitt cell lines, c-myc appears to have been translocated directly into a DNA rstriction fragment that also encodes the Ig .mu. chain gene. In a specific cloned fragment of DNA derived from a mouse plasmacytoma, c-myc has been translocated into the Ig .alpha. switch region. These data provide a molecular basis for considering the role that specific translocations might play in malignant transformation.