Phylogenetic Group Distribution of Uropathogenic Escherichia coli and Related Antimicrobial Resistance Pattern: A Meta-Analysis and Systematic Review.
Phylogenetic Group Distribution of Uropathogenic Escherichia coli and Related Antimicrobial Resistance Pattern: A Meta-Analysis and Systematic Review.
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DOI：
10.3389/fcimb.2022.790184
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发表时间：
2022
影响因子：
5.7
通讯作者：
Ranjbar R
中科院分区：
文献类型：
--
作者：
Halaji M;Fayyazi A;Rajabnia M;Zare D;Pournajaf A;Ranjbar R
大肠杆菌分离株的系统发育分类不仅对了解大肠杆菌的种群具有重要意义，大肠杆菌，也澄清菌株和疾病之间的关系。本研究的目的是评估泌尿系致病性大肠杆菌的系统发生群、抗生素敏感性模式和毒力基因的流行情况。大肠杆菌（UPEC）分离自伊朗不同地区，通过系统的审查和荟萃分析。检索了几个国际电子来源，包括Web of Science、PubMed、Scopus和Embase（2000-2020年），以确定符合我们纳入标准的研究。使用STATA（版本11）软件中的metaprop程序进行荟萃分析。基于我们的全面检索，28项符合资格标准的研究被纳入荟萃分析。B2、D、B1和A组的合并患病率分别为39%、26%、18%和8%。此外，不同年龄组之间存在显著的异质性。然而，根据Begg检验和Egger检验的结果，在B2、D、B1和A组中不存在显著的发表偏倚。这项研究提供了第一个全面的研究，在伊朗分离的UPEC的ESTA组。我们的研究结果表明，在伊朗各地区的UPEC分离物中，UPEC B2组和D组是最主要的系统发育组。此外，我们观察到某些系统发育组比其他组更耐抗生素。应采取综合感染控制措施，控制B2和D群强毒的传播。此外，应制定某些策略来监测抗生素治疗。
The phylogenetic classification of Escherichia coli isolates is of great importance not only for understanding the populations of E. coli but also for clarifying the relationship between strains and diseases. The present study aimed to evaluate the prevalence of phylogenetic groups, antibiotic susceptibility pattern, and virulence genes among uropathogenic E. coli (UPEC) isolated from different parts of Iran through a systematic review and meta-analysis. Several international electronic sources, including Web of Science, PubMed, Scopus, and Embase, were searched (2000–2020) in order to identify the studies compatible with our inclusion criteria. The meta-analysis was performed using the metaprop program in the STATA (version 11) software. Based on our comprehensive search, 28 studies meeting the eligibility criteria were included in the meta-analysis. The pooled prevalence of phylogroups B2, D, B1, and A was 39%, 26%, 18%, and 8%, respectively. In addition, there was a significant heterogeneity among different phylogroups. However, according to the results of Begg’s and Egger’s tests, there were no significant publication bias in phylogroups B2, D, B1, and A. This research provided the first comprehensive study on phylogroups of UPEC isolated in Iran. Our findings indicated that phylogroup B2 and group D were the most predominant phylogenetic groups among UPEC isolates in various regions of Iran. In addition, we observed that certain phylogenetic groups are more antibiotic resistant than the others. It was also observed that the dissemination of virulent phylogroup B2 and D should be controlled via comprehensive infection control measures. Additionally, certain strategies should be developed for monitoring the antibiotic therapy.