Human parainfluenza virus types 1-4 in hospitalized children with acute lower respiratory infections in China
Human parainfluenza virus types 1-4 in hospitalized children with acute lower respiratory infections in China
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DOI：
10.1002/jmv.24580
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发表时间：
2016-12-01
影响因子：
12.7
通讯作者：
Zhang, Bing
中科院分区：
文献类型：
--
作者：
Xiao, Ni-guang;Duan, Zhao-jun;Zhang, Bing
人副流感病毒（hpiv）是急性下呼吸道感染（ALRTIs）的重要病因。HPIV-4是一种新发现的病毒，最近与严重的呼吸道感染有关。2010年3月至2011年2月期间，共从住院儿童中收集了771份鼻咽吸入样本。采用Nest-PCR检测hpiv， RT-PCR和PCR检测其他已知呼吸道病毒。所有扩增产物测序。151例（19.58%）患者检出hpiv，其中HPIV-4阳性28例（3.63%），HPIV-1阳性12例（1.55%），HPIV-2阳性4例（0.51%），HPIV-3阳性107例（13.87%）。只有3人被发现同时感染了不同类型的hpiv。所有hpiv阳性儿童均在5岁以下，其中大多数为1岁以下儿童。只有HPIV-3的检出率在年龄间有显著的统计学差异（(2)=29.648，P=0.000）。HPIV-3和HPIV-4在夏季检测。共感染其他呼吸道病毒60例（39.74%），其中以人鼻病毒（HRV）最常见。临床诊断最多的是支气管肺炎，所有患者均有咳嗽；部分感染HPIV-3型和HPIV-4型的患者出现呼吸急促和发绀。感染HPIV-4型和HPIV-3型的临床表现无显著差异。两种HPIV-4基因型普遍存在，尽管HPIV-4a基因型占主导地位。HPIV-4是中国急性呼吸道感染住院儿童的一种重要病毒。HRV是最常见的共感染病毒。HPIV-4有两种基因型，以HPIV-4a为主。中华医学杂志，2016,33(4):391 - 391。(c) 2016 Wiley Periodicals, Inc.；
Human parainfluenza viruses (HPIVs) are an important cause of acute lower respiratory tract infections (ALRTIs). HPIV-4, a newly identified virus, has been associated with severe ALRTIs recently. A total of 771 nasopharyngeal aspirate samples were collected from hospitalized children between March 2010 and February 2011. HPIVs were detected by Nest-PCR, and other known respiratory viruses were detected by RT-PCR and PCR. All amplification products were sequenced. HPIVs were detected in 151 (19.58%) patients, of whom 28 (3.63%) were positive for HPIV-4, 12(1.55%) for HPIV-1, 4 (0.51%) for HPIV-2, and 107 (13.87%) for HPIV-3. Only three were found to be co-infected with different types of HPIVs. All HPIV-positive children were under 5 years of age, with the majority being less than 1 year. Only the detection rate of HPIV-3 had a significant statistical difference ((2)=29.648, P=0.000) between ages. HPIV-3 and HPIV-4 were detected during the summer. Sixty (39.74%) were co-infected with other respiratory viruses, and human rhinovirus (HRV) was the most common co-infecting virus. The most frequent clinical diagnosis was bronchopneumonia, and all patients had cough; some patients who were infected with HPIV-3 and HPIV-4 had polypnea and cyanosis. No significant difference was found in clinical manifestations between those who were infected with HPIV-4 and HPIV-3. Two genotypes for HPIV-4 were prevalent, although HPIV-4a dominated. HPIV-4 is an important virus for children hospitalized with ALRTIs in China. HRV was the most common co-infecting virus. Two genotypes for HPIV-4 are prevalent, HPIV-4a dominated. J. Med. Virol. 88:2085-2091, 2016. (c) 2016 Wiley Periodicals, Inc.