Comparing Clinical Perimetry and Population Receptive Field Measures in Patients with Choroideremia.
Comparing Clinical Perimetry and Population Receptive Field Measures in Patients with Choroideremia.
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DOI：
10.1167/iovs.18-23929
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发表时间：
2018-07-02
影响因子：
4.4
通讯作者：
Ashtari M
中科院分区：
文献类型：
--
作者：
Silson EH;Aleman TS;Willett A;Serrano LW;Pearson DJ;Rauschecker AM;Maguire AM;Baker CI;Bennett J;Ashtari M
脉络膜血症（CHM）是一种遗传视网膜变性的x连锁隐性形式，在晚期，只留下保存视网膜组织的小中心岛屿。与许多其他视网膜疾病不同，CHM的备用组织支持良好的中心视力和稳定的固定。在CHM中，这种保留的地形为利用功能磁共振成像（fMRI）探索保留的中央视网膜结构与视觉皮层视网膜组织之间的关系提供了理想的平台。在4名CHM患者和4名健康对照者单眼观看漂移对比模式刺激时进行功能磁共振成像。每只眼睛分别收集一次~ 3分钟的fMRI。使用群体感受野（pRF）建模方法对fMRI数据进行分析。参与者还接受了视力评估和静态自动验光。在大多数CHM患者中，pRF估计的空间分布和强度与临床结果测量呈正相关。重要的是，临床和pRF测量之间的正相关关系随着疾病进展的增加而增加。在对照组中观察到的关系不太一致。虽然只反映了小样本量，但通过使用单个~ 3分钟的fMRI实验，对CHM参与者的视觉功能的临床评估可以很好地表征pRF估计的空间分布和强度。功能磁共振成像数据分析与pRF模型可能是一个有效和客观的结果措施，以补充目前的眼科评估。具体而言，pRF建模可能是评估干预措施对恢复视觉功能影响的可行方法。
Choroideremia (CHM) is an X-linked recessive form of hereditary retinal degeneration, which, at advanced stages, leaves only small central islands of preserved retinal tissue. Unlike many other retinal diseases, the spared tissue in CHM supports excellent central vision and stable fixation. Such spared topography in CHM presents an ideal platform to explore the relationship between preserved central retinal structure and the retinotopic organization of visual cortex by using functional magnetic resonance imaging (fMRI). fMRI was conducted in four participants with CHM and four healthy control participants while they viewed drifting contrast pattern stimuli monocularly. A single ∼3-minute fMRI run was collected for each eye separately. fMRI data were analyzed using the population receptive field (pRF) modeling approach. Participants also underwent ophthalmic evaluations of visual acuity and static automatic perimetry. The spatial distribution and strength of pRF estimates correlated positively and significantly with clinical outcome measures in most participants with CHM. Importantly, the positive relationship between clinical and pRF measurements increased with increasing disease progression. A less consistent relationship was observed for control participants. Although reflecting only a small sample size, clinical evaluations of visual function in participants with CHM were well characterized by the spatial distribution and strength of pRF estimates by using a single ∼3-minute fMRI experiment. fMRI data analyzed with pRF modeling may be an efficient and objective outcome measure to complement current ophthalmic evaluations. Specifically, pRF modeling may be a feasible approach for evaluating the impact of interventions to restore visual function.
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影响因子：
13.7
作者：
Ashtari M;Nikonova ES;Marshall KA;Young GJ;Aravand P;Pan W;Ying GS;Willett AE;Mahmoudian M;Maguire AM;Bennett J
通讯作者：
Bennett J
影响因子：
2.5
作者：
Kay, Kendrick N.;Winawer, Jonathan;Wandell, Brian A.
通讯作者：
Wandell, Brian A.
DOI：
10.1073/pnas.1317074111
发表时间：
2014-04-22
影响因子：
11.1
作者：
Papanikolaou, Amalia;Keliris, Georgios A.;Smirnakis, Stelios M.
通讯作者：
Smirnakis, Stelios M.
影响因子：
3.7
作者：
Ashtari M;Cyckowski L;Yazdi A;Viands A;Marshall K;Bókkon I;Maguire A;Bennett J
通讯作者：
Bennett J
影响因子：
5.7
作者：
Lee, Sangkyun;Papanikolaou, Amalia;Keliris, Georgios A.
通讯作者：
Keliris, Georgios A.