Retinal nerve fiber layer analysis in RP patients using Fourier-domain OCT
Retinal nerve fiber layer analysis in RP patients using Fourier-domain OCT
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DOI：
10.1167/iovs.08-1842
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发表时间：
2008-08-01
影响因子：
4.4
通讯作者：
Fishman, Gerald A.
中科院分区：
文献类型：
--
作者：
Walia, Saloni;Fishman, Gerald A.
目的.采用傅立叶域光学相干断层扫描（Fd-OCT）检测视网膜色素变性（RP）患者视乳头周围视网膜神经纤维层厚度（RNFL），并评价黄斑囊样水肿（CME）或眼轴长度对RNFL测量的潜在影响。诊断为视网膜色素变性或Usher综合征II型的52例患者的97只眼接受了完整的眼部检查。使用Fd-OCT测量了4个象限的16个节段的乳头周围RNFL厚度-颞侧（316度-45度）、上级（46度-135度）、鼻侧（136度-225度）和下侧（226度-315度）。这些测量值与年龄和椎间盘大小调整的控制值进行了比较。进一步分析，以确定轴长或CME与RNFL厚度的相关性。23例（44.23%）37眼（38.14%）RNFL变薄。鼻象限变薄的眼数最多，其次是下象限;上级和颞象限异常变薄的眼数较少。在整个队列中，未发现眼轴长度与RNFL厚度之间存在相关性（相关系数为0.039）。21.65%的眼RNFL厚度异常增加，但CME的存在与RNFL厚度增加无关。RP眼睛在用Fd-OCT测试时可能显示出RNFL测量值的异常变薄或厚度增加。通过OCT测试观察到的RNFL缺陷记录了在相当数量的RP患者中视网膜内更前部结构中存在解剖缺陷。
PURPOSE. To determine peripapillary retinal nerve fiber layer thickness (RNFL) abnormalities in patients with retinitis pigmentosa (RP) using Fourier-domain optical coherence tomography (Fd-OCT) and to evaluate the potential effect of cystoid macular edema (CME) or axial length on RNFL measurements in such patients.METHODS. Ninety-seven eyes of 52 patients with diagnoses of retinitis pigmentosa or Usher syndrome type II underwent complete ocular examination. Peripapillary RNFL thickness was measured using Fd-OCT in 16 segments from 4 quadrants -temporal (316 degrees-45 degrees), superior (46 degrees-135 degrees), nasal (136 degrees-225 degrees), and inferior (226 degrees-315 degrees). These measurements were compared with age-and disc size-adjusted control values. Further analyses were performed to determine the correlation of axial length or CME with RNFL thickness.RESULTS. Thinning of the RNFL was observed in 37 eyes (38.14%) of 23 patients (44.23%). A maximum number of eyes had thinning in the nasal quadrant followed by the inferior quadrant; the superior and temporal quadrants were abnormally thin in fewer eyes. No correlation was found between axial length and RNFL thickness in the total cohort (correlation coefficient, 0.039). An abnormal increase in RNFL thickness was observed in 21.65% eyes, but no association was found between the presence of CME and increased RNFL thickness.CONCLUSIONS. RP eyes may show abnormal thinning or increased thickness of RNFL measurements on testing with Fd-OCT. RNFL defects observed by OCT testing document the presence of anatomic defects in more anterior structures within the retina in a notable number of patients with RP.