Intrahepatic expression of pro-inflammatory cytokine mRNAs and interferon efficacy in chronic hepatitis C.
Intrahepatic expression of pro-inflammatory cytokine mRNAs and interferon efficacy in chronic hepatitis C.
复制标题
促炎细胞因子 mRNA 的肝内表达和干扰素对慢性丙型肝炎的疗效。
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
S. Fukumoto
中科院分区：
文献类型：
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作者：
R. Fukuda;N. Ishimura;S. Ishihara;Aktaruzzaman Chowdhury;N. Moriyama;C. Nogami;T. Miyake;M. Niigaki;Alejandro Tokuda;S. Satoh;Shino Sakai;S. Akagi;M. Watanabe;S. Fukumoto
To investigate the relationship between intrahepatic cytokine expression and interferon (IFN) response in chronic hepatitis C [CH(C)], interleukin (IL)-1 beta, -2, -4, -6, -8, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha and TNF-beta mRNAs were investigated semiquantitatively by reverse transcription polymerase chain reaction using serial liver biopsies taken before and after IFN-alpha treatment from 24 patients with CH(C), including 12 responders and 12 non-responders. Before IFN treatment, IL-2, TNF-beta, IFN-gamma and IL-8 mRNA were associated with severe hepatitis activity whereas IL-4 mRNA was associated with weak hepatitis activity, regardless of IFN response. IL-2, TNF-beta and IFN-gamma mRNAs were significantly greater in IFN non-responders. After IFN treatment a complete response to IFN was significantly associated with the disappearance of these pro-inflammatory cytokines, whereas non-responders retained the expression of cytokine mRNA as before IFN treatment. Our results indicated that IFN-alpha treatment may modulate the intrahepatic cytokine network, and this may be one mechanism of IFN-alpha that reduces hepatitis activity, aside from an anti-viral effect. A difference in cytokine network may be involved in IFN response in CH(C).
影响因子：
158.5
作者：
CASTILLA, A;PRIETO, J;FAUSTO, N
通讯作者：
FAUSTO, N