Renin and hypertension.
Renin and hypertension.
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肾素和高血压。
DOI：
10.1001/jama.1979.03300050012009
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
W. Kirkendall
中科院分区：
文献类型：
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作者：
W. Kirkendall
致编辑Laragh及其同事在THE JOURNAL（241：151，1979）上发表的关于高血压患者诊断和治疗的肾素谱分析的文章，将肾素-血管紧张素系统置于其他体液物质的独特位置。它是否配得上比其他血管活性物质更高的地位还存在疑问。当人们试图使用作者的计划来预测成功的治疗时，许多失败强调了我们当时知识的不完整性。[1]文章中有一部分是关于肾素对高血压患者发病率的影响的，这是一个误导。在这篇文章中，作者指出，如果两个高血压患者血压相同，一个血浆肾素活性升高，一个血浆肾素活性低，医生对这两种疾病的进展和严重程度会有不同的态度，因此，对检查和治疗的方向和紧迫性也会有不同的态度。
To the Editor.— The article by Laragh and associates inTHE JOURNAL(241:151, 1979) concerning renin profiling for the diagnosis and treatment of hypertensive patients puts the renin-angiotensin system in a unique position in regard to other humoral substances. There is question whether it deserves this lofty position over other vasoactive materials. When one attempts to use the authors' plan for predicting successful therapy, the many failures emphasize the incompleteness of our knowledge at this time. 1 One section of the article that is misleading concerns the effect of renin on morbidity in the hypertensive patient. In the article, the authors indicate that given two hypertensive patients with equal blood pressures, one with an elevated plasma renin activity and one with low activity, the physician would have a different attitude of the pace and severity of the two disorders and, therefore, about both direction and urgency of workup and treatment