Choroidal Vascular Changes in Multiple Evanescent White Dot Syndrome
Choroidal Vascular Changes in Multiple Evanescent White Dot Syndrome
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DOI：
10.1080/09273948.2019.1678650
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发表时间：
2019-10-12
影响因子：
3.3
通讯作者：
Ciardella, Antonio P.
中科院分区：
文献类型：
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作者：
Pellegrini, Marco;Veronese, Chiara;Ciardella, Antonio P.
目的：评估多发性消失白点综合征（MEWDS）患者急性期和恢复期脉络膜结构的变化。方法：对 16 例单侧 MEWDS 患者在急性期和恢复期进行双眼增强深度成像光学相干断层扫描（EDI-OCT）扫描。使用 ImageJ 软件对图像进行二值化，测量中心凹下脉络膜厚度 (CT)、总脉络膜面积、管腔面积和脉络膜血管指数 (CVI)。结果：在急性期，MEWDS 眼的中心凹下 CT、总脉络膜面积和 CVI 显着高于其他眼（371.2 101.8 vs 317.1 +/- 90.3 μm，p = 0.001；2.826 +/- 0.686 与 2.524 +/- 0.674 mm(2)，p = 0.014；69.49 +/- 3.51 与 68.27 +/- 3.41%，p = 0.044）。在恢复阶段，MEWDS 眼的中心凹下 CT、脉络膜总面积和 CVI 显着下降，分别为 333.4 +/- 90.5 μm，p = .007、2.592 +/- 0.570 p = .002 和 67.31 +/- 2.74%，p = .014。结论：脉络膜厚度和血管分布在恢复期显着增加。 MEWDS 的急性期。
Purpose: To evaluate choroidal structural changes in patients with multiple evanescent white dot syndrome (MEWDS) during the acute and recovery stages.Methods: Enhanced-depth imaging optical coherence tomography (EDI-OCT) scans of 16 patients with unilateral MEWDS were acquired during the acute and recovery stages in both eyes. Images were binarized with the ImageJ software to measure subfoveal choroidal thickness (CT), total choroid area, luminal area and choroidal vascularity index (CVI).Results: In the acute stage, subfoveal CT, total choroidal area and CVI were significantly higher in eyes with MEWDS compared to fellow eyes (371.2 101.8 vs 317.1 +/- 90.3 mu m, p = .001; 2.826 +/- 0.686 vs 2.524 +/- 0.674 mm(2), p = .014; 69.49 +/- 3.51 vs 68.27 +/- 3.41%, p = .044, respectively). In the recovery stage, subfoveal CT, total choroidal area and CVI in eyes with MEWDS significantly decreased to respectively 333.4 +/- 90.5 mu m, p = .007, 2.592 +/- 0.570 p = .002, and 67.31 +/- 2.74%, p = .014.Conclusions: Choroidal thickness and vascularity are significantly increased during the acute stage of MEWDS.