Antagonistic analogs of luteinizing hormone-releasing hormone are mast cell secretagogues.
Antagonistic analogs of luteinizing hormone-releasing hormone are mast cell secretagogues.
复制标题
黄体生成素释放激素的拮抗类似物是肥大细胞促分泌素。
DOI：
10.1159/000234028
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Nekola,MV
中科院分区：
文献类型：
--
作者：
Morgan,JE;O'Neil,CE;Coy,DH;Hocart,SJ;Nekola,MV
The histamine-releasing activity of luteinizing hormone-releasing hormone (LHRH) antagonistic analogs has been documented. Antagonists of LHRH elicited in vitro histamine release from mast cells obtained from previously unexposed rats. Intradermal injection of the antagonists caused increased local skin permeability. Anaphylactoid reactions followed subcutaneous injection of the antagonists and in some cases these edematous reactions were accompanied by increased serum histamine levels. These studies show that these small peptides can cause mast cell degranulation and suggest that the neuropeptide, LHRH, may have modulating effects on the immune system.
