Interleukin (IL)-13/IL-22/IL-31 skewing within the skin-homing T-cell population in papuloerythroderma
Interleukin (IL)-13/IL-22/IL-31 skewing within the skin-homing T-cell population in papuloerythroderma
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DOI：
10.1111/1346-8138.15937
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发表时间：
2021-05-18
影响因子：
3.1
通讯作者：
Teraki, Yuichi
中科院分区：
文献类型：
--
作者：
Takamura, Saori;Teraki, Yuichi
丘疹性红皮病（Papuloerythroderma，PEO）是老年性红皮病的一种代表性疾病，其发病机制尚不清楚.本研究旨在表征负责PEO发病机制的T细胞表型。采用流式细胞术同时分析PEO患者循环T淋巴细胞上的细胞因子谱和皮肤淋巴细胞抗原（CLA）表达。与健康受试者相比，PEO患者循环中产生白细胞介素（IL）-4-、IL-13-、IL-22-和IL-31的CD 4（+）和CD 8（+）T细胞水平显著升高。然而，他们的水平显着下降缓解后PEO。在PEO患者和健康受试者之间，循环中产生干扰素（IFN）-γ和IL-17的CD 4（+）和CD 8（+）T细胞的比例没有观察到差异。特别是，循环中产生IL-4-、IL-13-、IL-22-和IL-31的CD 4（+）和CD 8（+）T细胞的比例在CLA（+）亚群中比在CLA（-）亚群中高得多。产生IL-13-、IL-22-和IL-31的CD 4（+）T细胞与PEO的疾病严重程度评分呈正相关。此外，在CD 4（+）和CD 8（+）T细胞中，还观察到IL-22或IL-31产生细胞与循环IL-13产生细胞的比例之间呈正相关，并且约50%的IL-22和IL-31产生的CD 4（+）和CD 8（+）T细胞共同产生IL-13。皮肤归巢T细胞群中的IL-13/IL-22/IL-31偏斜可能参与PEO的发病机制。
Papuloerythroderma (PEO) is a representative form of senile erythroderma with an unclear pathogenesis. This study aimed to characterize the T-cell phenotypes responsible for the pathogenesis of PEO. Cytokine profiles and cutaneous lymphocyte antigen (CLA) expression on circulating T lymphocytes in patients with PEO were simultaneously analyzed using flow cytometry. The patients with PEO showed significantly higher circulating interleukin (IL)-4-, IL-13-, IL-22-, and IL-31-producing CD4(+) and CD8(+) T-cell levels than healthy subjects. However, their levels significantly decreased after remission of PEO. No difference was observed in the proportions of circulating interferon (IFN)-gamma- and IL-17-producing CD4(+) and CD8(+) T cells between the patients with PEO and healthy subjects. In particular, the proportion of circulating IL-4-, IL-13-, IL-22-, and IL-31-producing CD4(+) and CD8(+) T cells was much higher in the CLA(+) subset than in the CLA(-) subset. There was a positive correlation between IL-13-, IL-22-, and IL-31-producing CD4(+) T cells and the disease severity score of PEO. Moreover, a positive correlation was also observed between the proportion of IL-22- or IL-31-producing cells and circulating IL-13-producing cells in both CD4(+) and CD8(+) T cells, and approximately 50% of both IL-22- and IL-31-producing CD4(+) and CD8(+) T cells coproduced IL-13. IL-13/IL-22/IL-31 skewing within the skin-homing T-cell population may be involved in the pathogenesis of PEO.