Age- and sex-related changes in fasting plasma glucose and lipoprotein in cynomolgus monkeys.
Age- and sex-related changes in fasting plasma glucose and lipoprotein in cynomolgus monkeys.
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食蟹猴空腹血糖和脂蛋白的年龄和性别相关变化。
DOI：
10.1186/s12944-016-0280-x
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发表时间：
2016-06-24
影响因子：
4.5
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Yue F;Zhang G;Tang R;Zhang Z;Teng L;Zhang Z
与年龄相关的糖脂代谢功能障碍与心血管和神经退行性疾病有长期的关系。然而，代谢功能障碍对男性和女性的影响是不同的。造成这些性别差异的原因尚不清楚。由于食蟹猴在生物学上与人类接近，过去曾被用于人类代谢性疾病的研究。然而，迄今为止，很少有研究关注葡萄糖和脂质代谢的年龄和性别差异。本研究旨在通过使用大型食蟹猴队列（N = 1,399）来专门解决这些问题，其中包括433只雄性和966只雌性，年龄在4至24岁之间。测定空腹血糖（FPG）和血脂参数，包括总胆固醇（T-Cho）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）。所有这些参数在年龄和性别之间进行了比较。在整个队列中，年龄与FPG、TG和HDL水平密切相关。因此，与性别相关的分析显示，女性的FPG、T-Cho、TG、HDL-C和LDL-C的平均水平明显高于男性。此外，更多的雌性猴子（28.5%）比雄性猴子（16%）符合空腹血糖受损（IFPG）。在这些IFPG动物中，也检测到性别相关的差异，即雌性的T-Cho、TG和LDL-C水平显著升高。该结果首次详细展示了雄性和雌性食蟹猴在与年龄相关的葡萄糖和脂蛋白代谢方面的异同，以及不同生理条件下的差异。详细的葡萄糖和脂蛋白分析应该为糖尿病前期提供额外和重要的见解。食蟹猴似乎是糖尿病转化研究和新治疗策略测试的一个很好的模型。
The age-related dysfunction of glucose and lipid metabolism has a long-standing relationship with cardiovascular and neurodegenerative disease. However, the effects of metabolic dysfunction on men and women are different. Reasons for these sex differences remains unclear. Cynomolgus monkeys have been used, in the past, for the study of human metabolic diseases due to their biologically proximity to humans. Nevertheless, few studies to date have focused on both age- and sex-related differences in glucose and lipid metabolism. The present study was designed to specifically address these questions by using a large cohort of cynomolgus monkeys (N = 1,399) including 433 males and 966 females with ages ranging 4 to 24 years old. Fasting plasma glucose (FPG) and lipid parameters including total cholesterol (T-Cho), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured. All these parameters were compared between ages and sexes. Among the entire cohort, age was strongly correlated with levels of FPG, TG and HDL. Consequently, sex-related analysis revealed that females had significantly higher average levels of FPG, T-Cho, TG, HDL-C and LDL-C than their male counterparts. In addition, more female (28.5 %) than male (16 %) monkeys qualified for impaired fasting plasma glucose (IFPG). In those IFPG animals, sex-related differences were also detected i.e. females had significantly increased levels of T-Cho, TG and LDL-C. The result, for the first time, demonstrated the similarities and differences in detail between male and female cynomolgus monkeys in relationship to age-related glucose and lipoprotein metabolisms, and differences under various physiological conditions. The detailed glucose and lipoprotein profiling should provide additional and important insights for prediabetic conditions. Cynomolgus monkeys appear to be an excellent model for translational research of diabetes and for novel therapeutic strategies testing to overt diabetes.