Biomaterials for Integration with 3-D Bioprinting
Biomaterials for Integration with 3-D Bioprinting
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DOI：
10.1007/s10439-014-1207-1
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发表时间：
2015-03-01
影响因子：
3.8
通讯作者：
Atala, Anthony
中科院分区：
文献类型：
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作者：
Skardal, Aleksander;Atala, Anthony
近年来，生物打印已成为一种在实验室中创建 3D 组织和器官的有吸引力的方法，因此在许多再生医学应用中是一项有前途的技术。它有潜力（i）为患者受损组织创建功能齐全的替代品，以及（ii）快速制造小型人体组织模型或类器官，用于诊断、病理建模和药物开发。人们已经探索了许多生物打印方式，包括细胞喷墨打印、基于挤出的技术、软光刻和激光诱导的正向转移。尽管每一项技术都有创新，但生物打印的成功实施在很大程度上依赖于与兼容的生物材料的集成，这些材料负责在生物制造期间和之后支持细胞组件，并且与生物打印设备的要求兼容。在这篇综述中，我们将评估各种生物材料，例如可固化合成聚合物、合成凝胶和天然水凝胶。具体来说，我们将描述它们如何与上述生物打印技术集成，以生成在医学中实际应用的生物打印结构。
Bioprinting has emerged in recent years as an attractive method for creating 3-D tissues and organs in the laboratory, and therefore is a promising technology in a number of regenerative medicine applications. It has the potential to (i) create fully functional replacements for damaged tissues in patients, and (ii) rapidly fabricate small-sized human-based tissue models, or organoids, for diagnostics, pathology modeling, and drug development. A number of bioprinting modalities have been explored, including cellular inkjet printing, extrusion-based technologies, soft lithography, and laser-induced forward transfer. Despite the innovation of each of these technologies, successful implementation of bioprinting relies heavily on integration with compatible biomaterials that are responsible for supporting the cellular components during and after biofabrication, and that are compatible with the bioprinting device requirements. In this review, we will evaluate a variety of biomaterials, such as curable synthetic polymers, synthetic gels, and naturally derived hydrogels. Specifically we will describe how they are integrated with the bioprinting technologies above to generate bioprinted constructs with practical application in medicine.