Is there a role for diet monotherapy in adult epilepsy?
Is there a role for diet monotherapy in adult epilepsy?
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DOI：
10.1016/j.ebcr.2016.09.005
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发表时间：
2017-01-01
影响因子：
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通讯作者：
Kossoff, Eric H.
中科院分区：
文献类型：
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作者：
Cervenka, Mackenzie C.;Henry-Barron, Bobbie J.;Kossoff, Eric H.
10名成人接受生酮饮食单药治疗癫痫。4例患者未接受过抗癫痫药物（ASD），6例患者曾尝试并停止ASD。在4名未经治疗的参与者中，2名（50%）在改良阿特金斯饮食（MAD）单药治疗>1年后未发生致残性癫痫发作。2例（50%）停止。6名曾尝试过ASD的患者中有4名（67%）在饮食单药治疗后无癫痫发作，2名患者癫痫发作减少>50%。副作用包括闭经、体重减轻、骨质疏松和高脂血症。饮食单药治疗可能是可行的，耐受性良好，有效的成年癫痫谁拒绝药物治疗和那些终身饮食治疗的建议。(C)2016年6月，作者。爱思唯尔公司出版这是一个CC BY-NC-ND许可下的开放获取文章。
Ten adults were treated with ketogenic diet monotherapy for epilepsy. Four patients were naive to antiseizure drugs (ASDs), and six previously tried and stopped ASDs. Of four treatment-naive participants, two (50%) were free from disabling seizures on Modified Atkins Diet (MAD) monotherapy for >1 year. Two (50%) stopped. Four of six patients (67%) who had previously tried ASDs became seizure-free on diet monotherapy, and two experienced >50% seizure reduction. Side effects included amenorrhea, weight loss, osteoporosis, and hyperlipidemia. Diet monotherapy may be feasible, well-tolerated, and effective for adults with epilepsy who refuse pharmacotherapy and those for whom lifelong diet therapy is recommended. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.