The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications.
The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications.
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DOI：
10.1016/j.tins.2008.07.003
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发表时间：
2008-10
影响因子：
15.9
通讯作者：
Brinton, Roberta Diaz
中科院分区：
文献类型：
--
作者：
Brinton, Roberta Diaz
“雌激素作用的健康细胞偏好”假说考察了调节线粒体功能和生物能量学在促进神经健康中的作用，以及雌激素暴露后导致不同结果的机械十字路口。海马和皮质神经元中雌激素诱导的信号通路会聚在线粒体上，以增强有氧糖酵解与柠檬酸循环、线粒体呼吸和ATP产生的耦合。当在患病神经元中激活时，雌激素诱导的信号传导到线粒体上的会聚也是脆弱点，其通过增加失调的钙稳态的负荷而加剧退化。随着神经健康的连续体从健康发展到不健康，雌激素或激素治疗的好处也是如此。雌激素作用假说的健康细胞偏好提供了一个透镜，通过它来评估基础和临床科学结果的差异，并预测雌激素干预的结果，以维持神经系统健康和预防与年龄相关的神经退行性疾病，如阿尔茨海默氏症。
The ‘healthy cell bias of estrogen action’ hypothesis examines the role that regulating mitochondrial function and bioenergetics play in promoting neural health and the mechanistic crossroads that lead to divergent outcomes following estrogen exposure. Estrogen-induced signaling pathways in hippocampal and cortical neurons converge upon the mitochondria to enhance aerobic glycolysis coupled to the citric acid cycle, mitochondrial respiration and ATP generation. Convergence of estrogen-induced signaling onto mitochondria is also a point of vulnerability when activated in diseased neurons which exacerbates degeneration through increased load on dysregulated calcium homeostasis. As the continuum of neurological health progresses from healthy to unhealthy so too do the benefits of estrogen or hormone therapy. The healthy cell bias of estrogen action hypothesis provides a lens through which to assess disparities in outcomes across basic and clinical science and on which to predict outcomes of estrogen interventions for sustaining neurological health and preventing age-associated neurodegenerative diseases such as Alzheimer s.
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影响因子：
4.8
作者：
Cheng, CM;Cohen, M;Bondy, CA
通讯作者：
Bondy, CA
DOI：
10.1111/j.1749-6632.2000.tb06370.x
发表时间：
2000-01-01
期刊：
VASCULAR FACTORS IN ALZHEIMER'S DISEASE
影响因子：
--
作者：
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通讯作者：
Gibson, GE
影响因子：
10.5
作者：
Gottlob, K;Majewski, N;Hay, N
通讯作者：
Hay, N
影响因子：
4.2
作者：
Brewer, GJ;Reichensperger, JD;Brinton, RD
通讯作者：
Brinton, RD
影响因子：
9.9
作者：
Henderson, VW;Paganini-Hill, A;Farlow, MR
通讯作者：
Farlow, MR