DIVERSITY IN G+C CONTENT AT THE 3RD POSITION OF CODONS IN VERTEBRATE GENES AND ITS CAUSE
DIVERSITY IN G+C CONTENT AT THE 3RD POSITION OF CODONS IN VERTEBRATE GENES AND ITS CAUSE
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DOI：
10.1093/nar/14.16.6345
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发表时间：
1986-08-26
影响因子：
14.9
通讯作者：
IKEMURA, T
中科院分区：
文献类型：
--
作者：
AOTA, S;IKEMURA, T
脊椎动物基因第三密码子的G+C含量与各基因周围基因组部分的G+C含量呈正相关。密码子第3位高G+C%的基因外显子被富含G+C的内含子和富含G+C的侧翼序列包围，而位于富含A+T的内含子和侧翼序列的低G+C%的基因外显子则被富含G+C的内含子和侧翼序列包围。使用DNA序列数据库对G+C含量沿DNA序列的分布进行分析，支持脊椎动物基因组是G+C含量存在明显差异的区域的镶嵌。结合染色体显带，讨论了脊椎动物基因组中G+C含量变化的生物学意义。
Correlation was positive between the G+C content at the codon third position in genes of vertebrates and the G+C content of the genome portion surrounding each gene. Exons of genes with a high G+C% at the codon 3rd position are surrounded by G+C-rich introns and G+C-rich flanking sequences, and those with a low G+C% at the position by A+T-rich introns and flanking sequences. Analysis of G+C content distribution along DNA sequences using a DNA Sequence Data Bank supported the view that the vertebrate genome is a mosaic of regions with clear differences in their G+C content. biological significance of thevariation in G+C content throughout the vertebrate genome is discussed in connection with chromosomal banding.