PATTERNS OF GROWTH AND METASTASES OF INDUCED PANCREATIC-CANCER IN RELATION TO THE PROGNOSIS AND ITS CLINICAL IMPLICATIONS
PATTERNS OF GROWTH AND METASTASES OF INDUCED PANCREATIC-CANCER IN RELATION TO THE PROGNOSIS AND ITS CLINICAL IMPLICATIONS
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DOI：
10.1016/0016-5085(91)90226-b
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发表时间：
1991-02-01
期刊：
影响因子：
29.4
通讯作者：
TAKIYAMA, Y
中科院分区：
文献类型：
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作者：
POUR, PM;EGAMI, H;TAKIYAMA, Y
为了了解胰腺癌的高度恶性，检查了在叙利亚仓鼠中诱导的胰腺癌的生长和转移模式。在该模型中，诱导的肿瘤在形态学、临床、生物学和免疫学上类似于人类疾病。在目前的研究中，主要诱导癌症和胰腺癌细胞系（PC-1）移植到SC组织或同源宿主的胰腺。在原发性胰腺癌中，神经周围浸润是最常见的途径（88%），其次是淋巴转移（31%）或血管转移（2%）。将PC-1细胞接种到胰腺中导致在3周内100%的肿瘤摄取。19例胰腺内移植物均出现腹膜浸润，5例（26%）肝转移，3例（16%）淋巴结转移，17例（89%）神经周围浸润，无血管浸润。即使是显微镜下的肿瘤也主要通过神经周围间隙转移。这也是第一次证明，癌细胞通过这条途径到达远处的组织，包括淋巴结。原发癌和胰腺内移植物均连续或不连续发生导管内扩散。乳腺导管内肿瘤的不连续扩张模式模仿肿瘤的多中心性。虽然神经周围浸润是原发癌和胰腺内移植物最常见的特征，但淋巴管、肝脏和血管浸润和转移通常发生在晚期病例。环境因素似乎会影响扩张和转移，这可以从SC和胰腺内同种异体移植物之间的生长和转移模式的差异中得到证明。
To understand high malignancy of pancreatic cancer, the growth and metastatic patterns of pancreatic cancer induced in Syrian hamsters were examined. In this model, induced tumors resemble the human disease morphologically, clinically, biologically, and immunologically. In the current study, primary-induced cancer and transplants of pancreatic cancer cell line (PC-1) into the SC tissue or pancreas of homologous hosts were used. In the primary-induced pancreatic cancer, perineural invasion was the most common path (88%), followed by lymphogenic (31%) or vascular (2%) metastases. Inoculation of PC-1 cells into the pancreas resulted in 100% tumor take within 3 weeks. Of 19 intrapancreatic allografts, all showed peritoneal invasion, 5 (26%) liver metastases, 3 (16%) lymph node metastases, 17 (89%) perineural invasion, and none vascular invasion. Even microscopic tumors were found to metastasize primarily via perineural spaces. It was also demonstrated, for the first time, that cancer cells take this route to reach distant tissues, including the lymph nodes. Intraductal spreading occurred in both primary cancers and intrapancreatic allografts either continuously or discontinuously. The patterns of discontinuous intraductal tumor expansion imitated tumor multicentricity. Although perineural invasion was the most common feature of primary cancer and intrapancreatic allografts, lymphatic, hepatic, and vascular invasion and metastases usually occurred in advanced cases. Environmental factors seem to influence expansion and metastases, as evidenced by differences in growth and in metastatic patterns between SC and intrapancreatic allografts.