Incidence of Parkinson's disease: Variation by age, gender, and Race/Ethnicity
Incidence of Parkinson's disease: Variation by age, gender, and Race/Ethnicity
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DOI：
10.1093/aje/kwg068
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发表时间：
2003-06-01
影响因子：
5
通讯作者：
Nelson, LM
中科院分区：
文献类型：
--
作者：
Van Den Eeden, SK;Tanner, CM;Nelson, LM
这项研究的目的是估计帕金森病的发病率，年龄，性别和种族。1994-1995年新诊断的帕金森病病例是在北方加州的Kaiser Permanente医疗保健计划（一个大型健康维护组织）的成员中确定的。每例病例均符合运动障碍专家采用的改良标准化标准/Hughes诊断标准。使用Kaiser Permanente成员信息作为分母计算每100，000人-年的发病率，并使用直接标准化方法对年龄和/或性别进行调整。共确定了588例新诊断的帕金森病（事件）病例，经年龄和性别调整的总体年发病率为13.4/100，000（95%置信区间（CI）：11.4，15.5）。发病率在60岁以上迅速增加，只有4%的病例在50岁以下。男性的发生率（19.0/100，000，95% CI：16.1，21.8）比女性高91%（9.9/100，000，95% CI：7.6，12.2）。每100，000人的年龄和性别调整率在西班牙裔中最高（16.6，95% CI：12.0，21.3），其次是非西班牙裔白人（13.6，95% CI：11.5，15.7），亚洲人（11.3，95% CI：7.2，15.3）和黑人（10.2，95% CI：6.4，14.0）。这些数据表明，帕金森病的发病率因种族/民族而异。
The goal of this study was to estimate the incidence of Parkinson's disease by age, gender, and ethnicity. Newly diagnosed Parkinson's disease cases in 1994-1995 were identified among members of the Kaiser Permanente Medical Care Program of Northern California, a large health maintenance organization. Each case met modified standardized criteria/Hughes diagnostic criteria as applied by a movement disorder specialist. Incidence rates per 100,000 person-years were calculated using the Kaiser Permanente membership information as the denominator and adjusted for age and/or gender using the direct method of standardization. A total of 588 newly diagnosed (incident) cases of Parkinson's disease were identified, which gave an overall annualized age- and gender-adjusted incidence rate of 13.4 per 100,000 (95% confidence interval (CI): 11.4, 15.5). The incidence rapidly increased over the age of 60 years, with only 4% of the cases being under the age of 50 years. The rate for men (19.0 per 100,000, 95% CI: 16.1, 21.8) was 91% higher than that for women (9.9 per 100,000, 95% CI: 7.6, 12.2). The age- and gender-adjusted rate per 100,000 was highest among Hispanics (16.6, 95% CI: 12.0, 21.3), followed by non-Hispanic Whites (13.6, 95% CI: 11.5, 15.7), Asians (11.3, 95% CI: 7.2, 15.3), and Blacks (10.2, 95% CI: 6.4, 14.0). These data suggest that the incidence of Parkinson's disease varies by race/ethnicity.