A longitudinal controlled study of factors associated with mutans streptococci infection and caries lesion initiation in children 21 to 72 months old.
A longitudinal controlled study of factors associated with mutans streptococci infection and caries lesion initiation in children 21 to 72 months old.
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作者：
V. Law;W. Seow
本纵向研究的目的是确定一组21至72个月的儿童中变形链球菌（MS）感染和龋齿病变发展的相关因素。方法：63名无龋儿童，自出生以来，被分为：（1）研究组24名儿童谁是殖民地与MS;和（2）对照组39名儿童没有MS。儿童每3个月召回约24个月，他们的社会，医疗和牙科史更新。在每次召回时，检查牙齿是否存在牙菌斑、釉质发育不全和龋齿病变，并使用商业测试试剂盒评估其MS状态。结果MS感染与以下因素相关：（1）可见菌斑（P <0.01）;（2）釉质发育不全（P <0.05）;（3）12个月后开始刷牙（P <0.05）;（4）缺乏父母刷牙帮助（P <0.025）;（5）儿童保育/上学时间增加（P <0.05）。4名儿童（20%）在21至36个月的年龄范围内定植，9名（45%）在37至48个月，7名（35%）在49至72个月（P < .001）。8名发生龋齿的儿童：（1）与未发生龋齿的儿童相比，有更多的发育不良牙齿（P <0.001）;（2）吃含糖零食（P <0.05）;（3）没有定期用洗必泰凝胶刷牙（P <0.01）。结论：缺乏口腔卫生、食用含糖零食和牙釉质发育不全是MS感染和龋病发生的重要因素。
PURPOSE The purpose of this longitudinal study was to determine factors associated with mutans streptococci (MS) infection and development of caries lesions in a group of children 21 to 72 months old. METHODS The 63 caries-free children, recruited since birth, were divided into: (1) a study group of 24 children who were colonized with MS; and (2) a control group of 39 children without MS. The children were recalled every 3 months for approximately 24 months, and their social, medical, and dental histories were updated. At each recall, the teeth were checked for presence or absence of plaque, enamel hypoplasia, and caries lesions, and their MS status was assessed using a commercial test kit. RESULTS MS infection was associated with: (1) visible plaque (P < .01); (2) enamel hypoplasia (P < .05); (3) commencement of tooth-brushing after 12 months of age (P < .05); (4) lack of parental assistance with tooth-brushing (P < .025); and (5) increased hours of child care/school (P < .05). Four children (20%) were colonized at an age range of 21 to 36 months, 9 (45%) at 37 to 48 months, and 7 (35%) at 49 to 72 months (P < .001). Eight children who developed caries lesions: (1) had more hypoplastic teeth (P < .001); (2) ate sugar-containing snacks (P < .05); and (3) did not brush regularly with chlorhexidine gel (P < .01) compared to those who remained free of caries lesions. CONCLUSIONS Lack of oral hygiene, consumption of sugar-containing snacks, and enamel hypoplasia are significant factors for both MS infection and caries lesion initiation.