GI Epidemiology: nonalcoholic fatty liver disease
GI Epidemiology: nonalcoholic fatty liver disease
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DOI：
10.1111/j.1365-2036.2007.03246.x
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发表时间：
2007-04-15
影响因子：
7.6
通讯作者：
Angulo, P.
中科院分区：
文献类型：
--
作者：
Angulo, P.
背景
非酒精性脂肪性肝病（NAFLD）是临床实践中常见的诊断。胰岛素抵抗和氧化应激在NAFLD的发生和发展中起重要作用。
目的
回顾有关NAFLD的流行病学和自然史的现有数据，以及其发生的危险因素和未来需要研究的领域。
结果/结论
NAFLD可能影响任何年龄范围和种族/族裔的个体。在美国，NAFLD影响三分之一的成年人以及十分之一的儿童/青少年。NAFLD患者的死亡率显著高于同年龄和性别的一般人群，肝脏相关并发症是常见的死亡原因。当NAFLD进展为晚期纤维化和肝硬化时，会出现肝脏相关的发病和死亡。有必要进一步研究以确定NAFLD对健康相关生活质量和资源利用的影响，以及预防代谢综合征的发生在多大程度上可预防NAFLD的发生并降低肝脏相关的发病和死亡率。生活方式干预可能改善NAFLD，但提高肝脏胰岛素敏感性和抗氧化防御的药物值得在严格控制的试验中进行评估。
Background Nonalcoholic fatty liver disease (NAFLD) is a common diagnosis in clinical practice. Insulin resistance and oxidative stress play an important role in NAFLD development and progression.Aim To review the data available on the epidemiology and natural history of NAFLD as well as the risk factors for its development and the areas where future research is necessary.Results/Conclusions NAFLD may affect individuals of any age range and race/ethnicity. NAFLD affects one in three adults and one in ten children/adolescents in the United States. Mortality in patients with NAFLD is significantly higher than in the general population of same age and gender with liver-related complications being a common cause of death. Liver-related morbidity and mortality in NAFLD occurs when the disease has progressed to advanced fibrosis and cirrhosis. Further studies are necessary to determine the impact of NAFLD on health-related quality of life and resources utilization, and to the extent to which preventing the development of the metabolic syndrome would prevent NAFLD development and reduce liver-related morbidity and mortality. Lifestyle intervention may improve NAFLD, but medications that increase insulin sensitivity and the antioxidant defenses in the liver deserve evaluation in carefully controlled trials.