Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.
Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.
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DOI：
10.1038/nrn2834
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发表时间：
2010-05
影响因子：
34.7
通讯作者：
Slesinger, Paul A.
中科院分区：
文献类型：
--
作者：
Luescher, Christian;Slesinger, Paul A.
G蛋白门控内向整流钾(GIRK)通道通过激活许多G蛋白偶联受体使神经元超极化，从而通过GIRK介导的自我抑制、慢突触电位和体积传递来控制神经元的兴奋性。GIRK通道的功能和贩运高度依赖于它们的亚基组成。对GIRK通道的药理学研究和动物模型研究表明，GIRK活性在包括痛觉和记忆调节在内的生理反应中起着重要作用。此外，GIRK功能异常与神经元兴奋性和细胞死亡的改变有关，这可能在癫痫、唐氏综合症、帕金森病和药物成瘾等人类疾病的病理生理学中起重要作用。因此，GIRK通道可能被证明是治疗这些健康问题的一个有价值的新治疗靶点。
G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in response to the activation of many G-protein coupled receptors and thus control the excitability of neurons through GIRK-mediated self-inhibition, slow synaptic potentials and volume transmission. GIRK channel function and trafficking are highly dependent on their subunit composition. Pharmacological investigations of GIRK channels and studies in animal models suggest that GIRK activity has an important role in physiological responses, including pain perception and memory modulation. Moreover, abnormal GIRK function has been implicated in altering neuronal excitability and cell death that may be important in the pathophysiology of human diseases such as epilepsy, Down’s syndrome, Parkinson’s disease and drug addiction. GIRK channels may therefore prove to be a valuable new therapeutic target for treating these health problems.
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DOI：
10.1073/pnas.222379999
发表时间：
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影响因子：
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作者：
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