Lower serum DHEAS levels are associated with a higher degree of physical disability and depressive symptoms in middle-aged to older African American women
Lower serum DHEAS levels are associated with a higher degree of physical disability and depressive symptoms in middle-aged to older African American women
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DOI：
10.1016/j.maturitas.2007.03.003
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发表时间：
2007-08-20
期刊：
影响因子：
4.9
通讯作者：
Morley, John E.
中科院分区：
文献类型：
--
作者：
Haren, Matthew T.;Malmstrom, Theodore K.;Morley, John E.
背景：中老年女性雄激素水平的变化及其与慢性疾病、生理和神经心理功能及残疾的关系尚不清楚，也没有在非裔美国女性中进行广泛的研究。目的：目前的横断面分析报告了来自密苏里州圣路易斯市49-65岁的非裔美国女性在社区居住中的这种水平和相关性。评估身体成分(DEXA)、下肢和手握力、身体和神经心理功能以及残疾程度。抽血测定总睾酮(T)、性激素结合球蛋白(SHBG)、硫酸脱氢表雄酮(DHEAS)、雌二醇(E2)、脂联素、瘦素、甘油三酯、血糖、C反应蛋白(CRP)和细胞因子受体(sIL2r、sIL6r、sTNFr1和sTNFR2)。采用多元线性回归模型对睾酮、DHEAS和游离雄激素指数(T/SHBG)进行预测。结果：74%的女性处于绝经期，其中四分之一正在接受雌激素治疗。DHEAs和E2在49-65岁之间下降，而总T、SHBG和FAI保持稳定。总T水平与DHEAS水平密切相关。在这一人群样本中，总T或FAI与功能受限、残疾或临床相关抑郁症状的指标没有独立的关联。与总T和FAI不同，较低的DHEAS水平与较高的IADL得分(表明身体残疾程度较高)和较高的CESD得分(指示较高的临床相关抑郁症状)独立相关。结论：非裔美国女性血清DHEAS水平存在年龄相关性下降。在该人群中，较低的DHEAS水平似乎与较高程度的身体残疾和抑郁症状有关。(C)2007爱思唯尔爱尔兰有限公司。保留所有权利。
Background: Changes in androgen levels and associations with chronic disease, physical and neuropsychological function and disability in women over the middle to later years of life are not well understood and have not been extensively studied in African American women.Aims: The present cross-sectional analysis reports such levels and associations in community dwelling, African American women aged 49-65 years from St. Louis, Missouri.Methods: A home-based physical examination and a health status questionnaire were administered to randomly sampled women. Body composition (DEXA), lower limb and hand-grip muscle strength, physical and neuropsychological function and disability levels were assessed. Blood was drawn and assayed for total testosterone (T), sex hormone-binding globulin (SHBG), dehydroepiandrosterone-sulfate (DHEAS), oestradiol (E2), adiponectin, leptin, triglycerides, glucose, C-reactive protein (CRP) and cytokine receptors (sIL2r, sIL6r, sTNFr1 and sTNFr2). Multiple linear regression modelling was used to identify the best predictors of testosterone, DHEAS and free androgen index (T/SHBG).Results: Seventy-four percent of women were menopausal and a quarter of these were taking oestrogen therapy. DHEAS and E2 declined between the ages of 49 and 65 years, whereas total T, SHBG and FAI remained stable. Total T and DHEAS levels were strongly correlated. In this population sample there were no independent associations of either total T or FAI with indicators of functional limitations, disability or clinically relevant depressive symptoms. Unlike total T and FAI, lower DHEAS levels wereindependently associated with both higher IADL scores (indicating a higher degree of physical disability) and higher CESD scores (indicating a higher degree of clinically relevant depressive symptoms).Conclusion: There is an age-related decline in serum DHEAS in African American women. Lower DHEAS levels appear to be associated with a higher degree of physical disability and depressive symptoms in this population. (c) 2007 Elsevier Ireland Ltd. All rights reserved.