MICROMETER-SCALE RESOLUTION IMAGING OF THE ANTERIOR EYE IN-VIVO WITH OPTICAL COHERENCE TOMOGRAPHY
MICROMETER-SCALE RESOLUTION IMAGING OF THE ANTERIOR EYE IN-VIVO WITH OPTICAL COHERENCE TOMOGRAPHY
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DOI：
10.1001/archopht.1994.01090240090031
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发表时间：
1994-12-01
影响因子：
--
通讯作者：
FUJIMOTO, JG
中科院分区：
文献类型：
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作者：
IZATT, JA;HEE, MR;FUJIMOTO, JG
目的：为了证明一种新的诊断技术，光学相干断层扫描，用于活体人眼前段结构的高分辨率横截面成像。光学相干断层扫描是一种新的、非侵入性的、非接触性的光学成像方式，其空间分辨率上级传统的临床超声检查（90 dB）。设计：眼内结构和尺寸测量的调查。设置：实验室。患者：方便样本。主要结果测量：与可接受的正常眼内结构轮廓和尺寸范围的相关性。结果：采用微米级分辨率对角膜厚度和表面轮廓（包括角膜上皮的可视化）、前房深度和角度以及虹膜厚度和表面轮廓进行直接体内测量。致密的核性白内障成功地成像，通过其全厚度的冷白内障模型在小牛的眼睛在vitrial.Conclusions：光学相干断层扫描有潜力作为一种诊断工具，在非接触式生物统计学的应用。前房角评估，眼内肿块和肿瘤的识别和监测，以及角膜、虹膜和晶状体透镜异常的说明。
Objective: To demonstrate a new diagnostic technique, optical coherence tomography, for high-resolution cross-sectional imaging of structures in the anterior segment of the human eye in vivo. Optical coherence tomography is a new, noninvasive, noncontact optical imaging modality that has spatial resolution superior to that of conventional clinical ultrasonography (90 dB).Design: Survey of intraocular structure and dimension measurements.Setting: Laboratory.Patients: Convenience sample.Main Outcome Measures: Correlation with range of accepted normal intraocular structure profiles and dimensions.Results: Direct in vivo measurements with micrometer-scale resolution were performed of corneal thickness and surface profile (including visualization of the corneal epithelium), anterior chamber depth and angle, and iris thickness and surface profile. Dense nuclear cataracts were successfully imaged through their full thickness in a cold cataract model in calf eyes in vitro.Conclusions: Optical coherence tomography has potential as a diagnostic tool for applications in noncontact biometry. anterior chamber angle assessment, identification and monitoring of intraocular masses and tumors, and elucidation of abnormalities of the cornea, iris, and crystalline lens.