Perirhinal cortex lesions impair feature-negative discrimination
Perirhinal cortex lesions impair feature-negative discrimination
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DOI：
10.1016/j.nlm.2006.03.001
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发表时间：
2006-09-01
影响因子：
2.7
通讯作者：
Freeman, John H.
中科院分区：
文献类型：
--
作者：
Campolattaro, Matthew M.;Freeman, John H.
研究了嗅周皮层在抑制性眨眼条件反射中的作用。在实验1中，大鼠被给予病变的围皮层或控制手术，随后训练的功能负歧视程序，然后由求和和延迟测试条件抑制。皮层损伤受损，但并没有阻止收购的功能负歧视。求和测试的结果表明，嗅周皮层损伤的大鼠不能将特征负性辨别概括为新的刺激。在阻滞试验期间没有组间差异。实验2表明，病变的围皮层不损害简单的兴奋性条件反射。实验3表明，皮层周围病变没有影响收购的一个简单的色调-光的歧视。结果表明，在眨眼条件反射中，当使用涉及重叠刺激的辨别程序时，嗅周皮层起作用。(c)2006爱思唯尔公司All rights reserved.
The role of the perirhinal cortex in inhibitory eyeblink conditioning was examined. In Experiment 1, rats were given lesions of the perithinal cortex or control surgery and subsequently trained with a feature-negative discrimination procedure followed by summation and retardation tests for conditioned inhibition. Perithinal cortex lesions impaired, but did not prevent acquisition of feature-negative discrimination. Results from the summation test showed that rats with perirhinal cortex lesions could not generalize feature-negative discrimination to a new stimulus. There were no group differences during the retardation test. Experiment 2 showed that lesions of the perithinal cortex did not impair simple excitatory conditioning. Experiment 3 showed that perithinal cortex lesions had no effect on acquisition of a simple tone-light discrimination. The results suggest that the perirhinal cortex plays a role in eyeblink conditioning when using discrimination procedures involving overlapping stimuli. (c) 2006 Elsevier Inc. All rights reserved.