Diabetes and depression? Secular trends in the use of antidepressants among persons with diabetes in Finland in 1997-2007
Diabetes and depression? Secular trends in the use of antidepressants among persons with diabetes in Finland in 1997-2007
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DOI：
10.1002/pds.2072
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发表时间：
2011-04-01
影响因子：
2.6
通讯作者：
Elovainio, Marko
中科院分区：
文献类型：
--
作者：
Manderbacka, Kristiina;Sund, Reijo;Elovainio, Marko
目的糖尿病和抑郁症之间的联系得到了很好的证明。人们对快速增长的糖尿病患者中抗抑郁药物的使用趋势知之甚少。我们使用基于登记的糖尿病和抗抑郁药使用数据，研究了1997-2007年间芬兰糖尿病患者和非糖尿病患者中抗抑郁药物的使用趋势。方法糖尿病人口来自FinDM II数据库，其中包括50027名接受胰岛素治疗(ITDM)的患者和346290名非胰岛素治疗糖尿病(NITDM)患者。非糖尿病患者的数据来自年度人口统计数据，以及非住院居民购买所有药品的退还处方药费用登记簿中的抗抑郁药使用情况。结果糖尿病患者中抗抑郁药物的使用在所有年龄组和每个研究年中在男女之间更为普遍(女性的患病率(RR)为1.4-2.2，男性为1.7-2.2)。NITDM患者的患病率较高(RR2.0-2.2女性，1.9-2.2男性)，且在患有NITDM的年轻人中增长更快。结论通过使用唯一的个人识别符关联的登记数据，我们可以识别整个糖尿病患者队列，区分ITDM和NITDM患者，并在11年的研究期间检查患有和不患有糖尿病的人群中抗抑郁药的使用模式。我们的结果表明，应该更多地关注糖尿病患者的心理健康，特别是有2型糖尿病风险的年轻人。版权所有(C)2010 John Wiley&Sons，Ltd.
Purpose The association between diabetes and depression is well demonstrated. Less is known about the trends in use of antidepressants in the rapidly growing population of diabetics. We examined trends in antidepressant medication use during 1997-2007 in Finland among persons with or without diabetes using register-based data on both diabetes and antidepressant use.Methods The diabetes population was obtained from the FinDM II database including 50 027 persons with insulin treated (ITDM) and 346 290 persons with non-insulin treated diabetes (NITDM) identified from several administrative registers. Data on persons without diabetes were obtained from the yearly population statistics and their antidepressant use from the register for refunded prescription medicine costs covering all medicine purchases of non-institutionalised residents. Differences in trends and prevalence were examined using the binomial regression model.Results Antidepressant use was more common among persons with diabetes in all age groups and each study year among both genders (prevalence ratios (RR) 1.4-2.2 for women and 1.7-2.2 for men). Prevalence was both higher (RR 2.0-2.2 women, 1.9-2.2 men), and increased more rapidly among younger persons with NITDM.Conclusions The use of register data linked using unique personal identifiers allowed us to identify a total cohort of persons with diabetes, to separate between ITDM and NITDM patients and to examine patterns of antidepressant use in populations with and without diabetes during an 11 year study period. Our results suggest that more attention should be focused on psychological well-being in those with diabetes and especially young people in risk of type 2 diabetes. Copyright (C) 2010 John Wiley & Sons, Ltd.