Serum levels of polyamine synthesis enzymes increase in diabetic patients with breast cancer.
Serum levels of polyamine synthesis enzymes increase in diabetic patients with breast cancer.
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DOI：
10.1530/ec-17-0137
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发表时间：
2017-11
影响因子：
2.9
通讯作者：
Kılıçgün H
中科院分区：
文献类型：
--
作者：
Çelik VK;Kapancık S;Kaçan T;Kaçan SB;Kapancık S;Kılıçgün H
本研究旨在探讨糖尿病与乳腺癌的关系，以及糖尿病、乳腺癌和糖尿病乳腺癌患者多胺合成途径中酶和鸟氨酸水平的检测。在所有组的血清中测量了鸟氨酸、精氨酸脱羧酶、鸟氨酸脱羧酶和胍丁胺酶水平。鸟氨酸水平通过荧光光度法测量。精氨酸脱羧酶、鸟氨酸脱羧酶和胍丁胺酶水平用ELISA试剂盒测定。除糖尿病组外，其余各组多胺合成途径中的酶水平均升高，差异有统计学意义（P < 0.05）。其中胍丁胺酶的升高最为显著（P < 0.001）。糖尿病患者多胺合成酶水平降低，乳腺癌患者多胺合成酶水平升高。基于糖尿病的乳腺癌发展是否以及如何与负责多胺合成的酶的活性增加有关，需要在更大的患者队列中进行进一步的机制和前瞻性监测研究。
In this study, it was aimed to investigate the relationship between diabetes and breast cancer and the detection of enzymes and ornithine levels in polyamine synthesis pathway in diabetes, breast cancer and diabetic breast cancer patients. Ornithine, arginine decarboxylase, ornithine decarboxylase and agmatinase levels have been measured in serum of all groups. Ornithine levels were measured spectrophotometrically. Arginine decarboxylase, ornithine decarboxylase and agmatinase levels were determined by ELISA kits. Except for the diabetic group, the levels of enzymes in the polyamine synthesis pathway were increased in all and statistically significant (P < 0.05). The increase in the levels of agmatinase was very important among the enzymes (P < 0.001). Decreased levels of polyamine synthase enzymes in diabetes mellitus were found to be increased patients with breast cancer. Whether and how diabetes-based breast cancer development relates to increase activity of enzymes responsible for polyamine synthesis requires further mechanistic and prospective monitoring studies in larger patient cohorts.