Altered endochondral ossification in collagen X mouse models leads to impaired immune responses.
Altered endochondral ossification in collagen X mouse models leads to impaired immune responses.
复制标题
X 胶原蛋白小鼠模型中软骨内骨化的改变会导致免疫反应受损。
DOI：
10.1002/dvdy.21594
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Jacenko,O
中科院分区：
文献类型：
--
作者：
Sweeney,E;Campbell,M;Watkins,K;Hunter,CA;Jacenko,O
造血系统疾病，如骨髓衰竭，免疫功能障碍，以及免疫-骨疾病可能涉及软骨内骨骼和骨髓之间的直接联系。因此，了解骨髓环境是如何建立的，是什么使这个网站优先造血，哪些骨骼缺陷可能有助于骨髓改变和受损的造血分化，可能是关键的诊断和治疗各种免疫骨，以及造血diseases.During脊椎动物的发展，造血成为顺序重建在几个解剖学上不同的网站。然而，骨髓是出生后血细胞生成的主要部位（Aguila和Rowe，2005），并与软骨内骨化（EO）发育相关（Chan和Jacenko，1998;列费夫尔和Smits，2005）。在EO过程中，软骨原基的产生作为轴向和无骨骨骼以及某些颅骨的蓝图，并确定所有未来的骨骼元素，其中功能性骨髓空间
Hematopoietic disorders such as bone marrow failure, immune dysfunction, as well as immuno-osseous disorders may involve a direct link between the endochondral skeleton and the marrow. Thus, understanding how a marrow environment is established, what makes this site preferential for hematopoiesis, and which skeletal defects may contribute to marrow alterations and impaired hematopoietic differentiation, may be key for the diagnosis and treatment of various immuno-osseous, as well as hematopoietic diseases.During vertebrate development, hematopoiesis becomes sequentially reestablished in several anatomically distinct sites. However, the bone marrow represents the predominant site of blood cell production after birth (Aguila and Rowe, 2005) and is developmentally linked to endochondral ossification (EO)(Chan and Jacenko, 1998; Lefebvre and Smits, 2005). During EO, the generation of a cartilage anlage serves as a blueprint for the axial and appendicular skeleton, as well as for certain cranial bones, and identifies all future skeletal elements where a functional marrow space