Haloperidol reduces the sympathetic and thermogenic activation induced by orexin A
Haloperidol reduces the sympathetic and thermogenic activation induced by orexin A
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DOI：
10.1016/s0168-0102(02)00191-8
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发表时间：
2003-01-01
影响因子：
2.9
通讯作者：
De Luca, V
中科院分区：
文献类型：
--
作者：
Monda, M;Viggiano, A;De Luca, V
本实验观察了氟哌啶醇对增食欲素A引起的交感和发热效应的影响。在乌拉坦麻醉的雄性SD大鼠侧脑室注射食欲素A(1.5nmol)前和注射后5h，监测交感神经对肩峰间棕色脂肪组织(BAT)的放电率、IBAT、结肠温度和心率。在用D-2受体拮抗剂氟哌啶醇(1 mg/kg bw)腹腔注射的大鼠中也监测到了同样的变量。结果表明，增食欲素A可增加交感神经放电频率、IBAT、结肠温度和心率。这一增加被氟哌啶醇所减少。这些发现表明，在增食欲素A诱导的体温升高过程中，多巴胺能系统被激活。(C)2002年爱思唯尔爱尔兰科学有限公司和日本神经科学学会。版权所有。
This experiment tested the effect of haloperidol on the sympathetic and thermogenic effects induced by orexin A. The firing rates of the sympathetic nerves to interscapular brown adipose tissue (BAT), along with IBAT and colonic temperatures and heart rate were monitored in urethane-anesthetized male Sprague-Dawley rats before and 5 h after an injection of orexin A (1.5 nmol) into the lateral cerebral ventricle. The same variables were monitored in rats with an intraperitoneal administration of haloperidol (1 mg/kg bw), a D-2 receptor antagonist. The results show that orexin A increases the sympathetic firing rate, IBAT and colonic temperatures and heart rate. This increase is reduced by the haloperidol. These findings suggest that dopaminergic system is activated during the orexin A-induced hyperthermia. (C) 2002 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.