Progression of Idiopathic Pulmonary Fibrosis Is Associated with Silica/Silicate Inhalation
Progression of Idiopathic Pulmonary Fibrosis Is Associated with Silica/Silicate Inhalation
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DOI：
10.1021/acs.estlett.1c00659
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发表时间：
2021-09-23
影响因子：
10.9
通讯作者：
Dobashi, Kunio
中科院分区：
文献类型：
--
作者：
Koga, Yasuhiko;Satoh, Takahiro;Dobashi, Kunio
最近，环境粉尘暴露已成为间质性肺炎的可能危险因素。吸入二氧化硅/硅酸盐和钛与快速进展的尘肺病的进展有关。然而，吸入元素与特发性肺纤维化（IPF）之间的关系仍不清楚。在本研究中，我们重点关注表现为组织学常见间质性肺炎的 IPF，并研究吸入元素与 IPF 进展之间的关系。我们使用空气中微粒诱导 X 射线发射分析 (PIXE) 检查了肺部的元素。对 IPF 肺组织样本进行分析并与对照肺样本进行比较。 IPF 和对照肺之间在硅方面存在显着差异，假设形成二氧化硅/硅酸盐。肺部吸入硅与 IPF 患者用力肺活量的年度下降显着相关。此外，与肺部硅积累较低的患者相比，硅积累较高的 IPF 患者的预后明显较差。这些显着差异也出现在多变量分析中，包括吸烟史、IPF 严重程度和/或抗纤维化治疗。空气中的微型 PIXE 有助于检测肺部吸入的元素。这些结果表明，肺部吸入的二氧化硅/硅酸盐可能部分参与了 IPF 的进展。
Recently, environmental dust exposure has emerged as a possible risk factor for interstitial pneumonia. Inhaled silica/silicates and titanium are associated with the progression of rapidly progressive pneumoconiosis. However, the relationship between inhaled elements and idiopathic pulmonary fibrosis (IPF) remains unclear. In this study, we focused on IPF presenting with histological usual interstitial pneumonia and investigated the relationship between inhaled elements and IPF progression. We examined the elements in the lungs using in-air micro-particle-induced X-ray emission analysis (PIXE). Lung tissue samples with IPF were analyzed and compared with control lung samples. There was a significant difference between IPF and the control lungs in terms of silicon, assumed to form silica/silicates. Inhaled silicon in the lungs significantly correlated with the annual decline in forced vital capacity in patients with IPF. Furthermore, IPF patients with higher accumulation of silicon showed a significantly poorer prognosis than those with lower accumulation of silicon in the lungs. These significant differences were also seen in multivariate analyses, including smoking history, IPF severity, and/or antifibrotic treatment. In-air micro-PIXE can be beneficial for detecting inhaled elements in the lung. These results indicate that inhaled silica/silicates in the lung may be partly involved in the progression of IPF.