Long non-coding RNAs: a rising biotarget in colorectal cancer.
Long non-coding RNAs: a rising biotarget in colorectal cancer.
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长链非编码RNA：结直肠癌中新兴的生物靶点
DOI：
10.18632/oncotarget.14728
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发表时间：
2017-03-28
期刊：
影响因子：
--
通讯作者：
Qu Q
中科院分区：
文献类型：
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作者：
Luo J;Qu J;Wu DK;Lu ZL;Sun YS;Qu Q
结直肠癌(CRC)是常见的胃肠道肿瘤，发病率高，死亡率高。长非编码RNA(Long Non-Coding RNAs，LncRNAs)通过干扰mRNA的活性，直接与蛋白质结合调节其活性或改变其定位，参与结直肠癌的发生、侵袭和转移、早期诊断、预后、化疗耐药和辐射耐药，通过抑制RNA聚合酶影响下游基因表达，作为竞争内源性RNA调节基因表达。新一代测序和转录组分析的最新进展表明，组织和癌症类型特异的lncRNAs可能是有用的预后标记物。在这里，回顾了从最近的研究到2016年10月为止与CRC相关的LncRNAs，并总结了已证实与CRC相关的LncRNAs的多项研究。这一综述可能有助于理解CRC中涉及的LncRNAs之间的总体关系。
Colorectal cancer (CRC) is a common gastrointestinal cancer, with a high incidence and high mortality. Long non-coding RNAs (lncRNAs) are involved in the development, invasion and metastasis, early diagnosis, prognosis, the chemoresistance and radioresistance of CRC through interference with mRNA activity, directly combining with proteins to regulate their activity or alter their localization, influencing downstream gene expression by inhibiting RNA polymerase and regulating gene expression as competing endogenous RNAs. Recent progress in next generation sequencing and transcriptome analysis has revealed that tissue and cancer-type specific lncRNAs could be useful prognostic markers. Here, the CRC-associated lncRNAs from recent studies until October 2016 are reviewed and multiple studies that have confirmed CRC-associated lncRNAs are summarized. This review may be helpful in understanding the overall relationships between the lncRNAs involved in CRC.