No Difference Between High-Fructose and High-Glucose Diets on Liver Triacylglycerol or Biochemistry in Healthy Overweight Men
No Difference Between High-Fructose and High-Glucose Diets on Liver Triacylglycerol or Biochemistry in Healthy Overweight Men
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DOI：
10.1053/j.gastro.2013.07.012
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发表时间：
2013-11-01
期刊：
影响因子：
29.4
通讯作者：
Macdonald, Ian A.
中科院分区：
文献类型：
--
作者：
Johnston, Richard D.;Stephenson, Mary C.;Macdonald, Ian A.
背景与目的：高果糖饮食被认为与非酒精性脂肪性肝病有关。我们比较了高果糖和匹配葡萄糖摄入量对肝脏三酰甘油(TAG)浓度和其他肝脏参数的影响。设计：在一项双盲研究中，我们随机将32名健康但中度超重的男性分配到接受高果糖或高葡萄糖饮食(25%能量)的组。这些饮食是在2周的初始等卡路里期间提供的，随后是6周的洗涤期，然后在高热量的2周期间再次提供。主要的结果衡量指标是肝脏的TAG水平，以及血清和比目鱼肌中的TAG水平、肝脏的三磷酸腺苷水平以及全身和肝脏的胰岛素抵抗。结果：在研究的等量热量期间，两组的体重和肝脏、血清和比目鱼肌中的TAG浓度都是稳定的。高果糖组大鼠血清尿酸水平升高22+/-52MU/L，而高糖组大鼠血清尿酸水平降低23/-25MU/L(P<；0.01)。在胰岛素抵抗的稳态模型评估中，高果糖饮食也产生了0.8+/-0.9的增加，而高葡萄糖饮食只产生了0.1+/-0.7的增加(P=0.03)。在高热量期间，高果糖和高葡萄糖组的受试者在体重(1.0+/-1.4vs0.6+/-1.0 kg；P=.29)和肝脏中TAG的绝对浓度(1.70%+/-2.6%vs2.05%+/-2.9%；P=.)和血清(0.36+/-0.75vs0.33+/-0.38 mmol/L；P=.91)方面有相似的增长，在肝功能的生化分析中也有类似的结果。体重的变化与肝脏生化和TAG浓度的变化有关。结论：在等卡路里期间，高果糖或高糖饮食的超重男性在肝脏TAG浓度或血清肝酶水平方面没有发生任何显著变化。然而，在高热量时期，高果糖和高葡萄糖饮食都显著增加了这些参数，但两组之间没有任何显著差异。这表明这是一种能量调节的效应，而不是特定的常量营养素调节的效应。
BACKGROUND & AIMS: Diets high in fructose have been proposed to contribute to nonalcoholic fatty liver disease. We compared the effects of high-fructose and matched glucose intake on hepatic triacylglycerol (TAG) concentration and other liver parameters. DESIGN: In a double-blind study, we randomly assigned 32 healthy but centrally overweight men to groups that received either a high-fructose or high-glucose diet (25% energy). These diets were provided during an initial isocaloric period of 2 weeks, followed by a 6-week washout period, and then again during a hypercaloric 2-week period. The primary outcome measure was hepatic level of TAG, with additional assessments of TAG levels in serum and soleus muscle, hepatic levels of adenosine triphosphate, and systemic and hepatic insulin resistance. RESULTS: During the isocaloric period of the study, both groups had stable body weights and concentrations of TAG in liver, serum, and soleus muscle. The high-fructose diet produced an increase of 22 +/- 52 mu mol/L in the serum level of uric acid, whereas the high-glucose diet led to a reduction of 23 +/- 25 mu mol/L (P < .01). The high-fructose diet also produced an increase of 0.8 +/- 0.9 in the homeostasis model assessment of insulin resistance, whereas the high-glucose diet produced an increase of only 0.1 +/- 0.7 (P = .03). During the hypercaloric period, participants in the high-fructose and high-glucose groups had similar increases in weight (1.0 +/- 1.4 vs 0.6 +/- 1.0 kg; P = .29) and absolute concentration of TAG in liver (1.70% +/- 2.6% vs 2.05% +/- 2.9%; P = ) and serum (0.36 +/- 0.75 vs 0.33 +/- 0.38 mmol/L; P = .91), and similar results in biochemical assays of liver function. Body weight changes were associated with changes in liver biochemistry and concentration of TAGs. CONCLUSIONS: In the isocaloric period, overweight men who were on a high-fructose or a high-glucose diet did not develop any significant changes in hepatic concentration of TAGs or serum levels of liver enzymes. However, in the hypercaloric period, both high-fructose and high-glucose diets produced significant increases in these parameters without any significant difference between the 2 groups. This indicates an energy-mediated, rather than a specific macronutrient-mediated, effect.