Seeking new anti-cancer agents from autophagy-regulating natural products
Seeking new anti-cancer agents from autophagy-regulating natural products
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从调节自噬的天然产物中寻找新的抗癌药物
DOI：
10.1080/10286020.2017.1304385
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发表时间：
2017-01-01
影响因子：
1.7
通讯作者：
Hu, Zhuo-Wei
中科院分区：
文献类型：
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作者：
Hua, Fang;Shang, Shuang;Hu, Zhuo-Wei
摘要天然产物是包括抗癌药物在内的许多常用药物的重要来源。早期从天然产物中寻找抗癌药物的研究主要集中在具有细胞毒性的化合物上。好的例子包括长春碱、长春新碱、喜树碱衍生物;拓扑替康、伊立替康、表鬼臼毒素衍生物和紫杉醇。近10年来，人们对肿瘤发生、转移、耐药、免疫逃逸和复发的分子和细胞机制的认识取得了重大进展，这为开发基于机制的抗肿瘤药物，特别是针对新的分子和细胞靶点的药物提供了巨大的机遇。自噬是一种重要的细胞自稳机制，是治疗癌症等多种人类疾病的重要药物靶点，许多天然产物都能调控自噬。本文就自噬的相关研究进展作一综述，并探讨自噬在肿瘤发生、发展中的作用。在此基础上，总结了近年来天然产物中的几种化合物通过调节自噬活性而发挥抗肿瘤作用的研究进展。
Abstract Natural products are an important original source of many widely used drugs, including anti-cancer drugs. Early research efforts for seeking anti-cancer therapy from the natural products are mainly focused on the compounds with cytotoxicity capability. The good examples include vinblastine, vincristine, the camptothecin derivatives; topotecan, irinotecan, epipodophyllotoxin derivatives and paclitaxel. In a recent decade, the fundamental progression has been made in the understanding of molecular and cellular mechanisms regarding tumor initiation, metastasis, therapeutic resistance, immune escape, and relapse, which provide a great opportunity for the development of new mechanism-based anticancer drugs, especially drugs against new molecular and cellular targets. Autophagy, a critical cell homeostasis mechanism and promising drug target involved in a verity of human diseases including cancer, can be modulated by many compounds derived from natural products. In this review, we’ll give a short introduction of autophagy and discuss the roles of autophagy in the tumorigenesis and progression. And then, we summarize the accumulated evidences to show the anti-tumor effects of several compounds derived from natural products through modulation of autophagy activity.