Reducing multiple births in assisted reproduction technology
Reducing multiple births in assisted reproduction technology
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DOI：
10.1016/j.bpobgyn.2013.11.005
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发表时间：
2014-02-01
影响因子：
5.5
通讯作者：
Kamath, Mohan S.
中科院分区：
文献类型：
--
作者：
Bhattacharya, Siladitya;Kamath, Mohan S.
多胎妊娠是辅助生殖技术的一种并发症，与较差的母亲和围产儿结局有关。这背后的主要原因是在辅助生殖技术周期中替换一个以上胚胎的策略，以最大限度地提高怀孕率。解决这个问题的办法是减少体外受精过程中移植的胚胎数量。从三胎胚胎移植到双胚胎移植的过渡很容易实现，它在不影响怀孕率的情况下降低了三胞胎的风险。由于担心新鲜辅助生殖技术周期中的妊娠率受损，单一胚胎移植政策的采用一直很缓慢。有效的冷冻保存方案的广泛应用意味着选择性的单一胚胎移植，以及随后的冷冻胚胎移植，可能提供一条前进的道路。任何这样的策略都需要考虑夫妇的偏好和现有的资金政策，这两者都对胚胎移植的决策产生了深远的影响。(C)2013爱思唯尔有限公司。保留所有权利。
Multiple pregnancy, a complication of assisted reproduction technology, is associated with poorer maternal and perinatal outcomes. The primary reason behind this is the strategy of replacing more than one embryo during an assisted reproduction technology cycle to maximise pregnancy rates. The solution to this problem is to reduce the number of embryos transferred during invitro fertilisation. The transition from triple-to double-embryo transfer, which decreased the risk of triplets without compromising pregnancy rates, was easily implemented. The adoption of a single embryo transfer policy has been slow because of concerns about impaired pregnancy rates in a fresh assisted reproduction technology cycle. Widespread availability of effective cryopreservation programmes means that elective single embryo transfer, along with subsequent frozen embryo transfers, could provide a way forward. Any such strategy will need to consider couples' preferences and existing funding policies, both of which have a profound influence on decision making around embryo transfer. (C) 2013 Elsevier Ltd. All rights reserved.