The taxanes: toxicity and quality of life considerations in advanced ovarian cancer.
The taxanes: toxicity and quality of life considerations in advanced ovarian cancer.
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紫杉虫：晚期卵巢癌的毒性和生活质量注意事项。
DOI：
10.1038/sj.bjc.6601496
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发表时间：
2003-12
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
紫杉烷类药物紫杉醇和多西他赛与铂类药物联合治疗晚期卵巢癌时显示出良好的活性。来自临床研究的累积证据，特别是来自III期比较SCOTROC研究的最新结果，表明这两种药物在患有这种疾病的女性中具有相似的肿瘤反应率和生存率。然而，很明显，紫杉醇和多西他赛在耐受性特征和其他方面存在差异，不能视为直接等效药物。特别是，紫杉醇与显著的神经毒性相关;多西他赛也报告了周围神经病变，但程度较轻。多西他赛的中性粒细胞增多症似乎比紫杉醇更常见，尽管临床试验数据显示这种不良反应是可控的，不需要影响剂量输送。多西他赛还与较短的输注时间和不需要静脉注射组胺H1和H2拮抗剂的前驱用药的潜在益处有关。新出现的生活质量数据有望进一步阐明化疗在晚期卵巢癌女性中的总体获益，特别是紫杉烷-铂联合治疗。
The taxanes paclitaxel and docetaxel show good activity in the management of advanced ovarian cancer when used in conjunction with platinum agents. Accumulating evidence from clinical studies, particularly the latest results from the phase III comparative SCOTROC study, indicates that the two drugs confer similar rates of tumour response and survival in women with this condition. However, it is clear that paclitaxel and docetaxel differ in their tolerability profiles and in other respects, and cannot be regarded as directly equivalent drugs. In particular, paclitaxel is associated with significant neurotoxicity; peripheral neuropathy has also been reported with docetaxel, but to a lesser extent. Neutropenia appears more prevalent with docetaxel than with paclitaxel, although clinical trial data show that this adverse effect is manageable and need not compromise dose delivery. Docetaxel is also associated with potential benefits accruing from shorter infusion times and lack of need for premedication with intravenous histamine H1 and H2 antagonists. Emerging quality of life data are expected to shed further light on the overall benefit of chemotherapy in women with advanced ovarian cancer in general, and on taxane−platinum combinations in particular.
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