INCREMENTAL REPEATED ACQUISITION IN THE RAT - ACUTE EFFECTS OF DRUGS
INCREMENTAL REPEATED ACQUISITION IN THE RAT - ACUTE EFFECTS OF DRUGS
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DOI：
10.1016/s0091-3057(84)80106-9
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发表时间：
1984-01-01
影响因子：
3.6
通讯作者：
MCMILLAN, DE
中科院分区：
文献类型：
--
作者：
PAULE, MG;MCMILLAN, DE
大鼠杠杆挤压食物，并学习了3个杠杆的新反应序列。在每一天的开始，只有一个杠杆的反应产生食物。在满足一个杠杆上的标准后，任务增加，因此需要2个杠杆上的顺序响应，依此类推，最多5个顺序响应。将每个新的所需响应添加到先前执行的序列之前。生产食物所需的杠杆按压顺序每次都会改变。在建立稳定的获得行为后，观察了d-苯丙胺（0.30-3.0 mg/kg）、地西泮（0.125-4.0 mg/kg）、吗啡（0.30-10.0 mg/kg）、戊巴比妥（1.0-17.5 mg/kg）和氯丙嗪（0.10-3.0 mg/kg）的急性效应。所有药物均以剂量依赖性方式减少完成的反应序列数量。响应率通常在或低于导致错误增加的剂量时下降。对于d-安非他明，增量重复获取行为的深刻破坏主要是由于药物诱导的持续反应。戊巴比妥和氯丙嗪增加错误时，序列增加和序列内，而地西泮只增加错误时，序列增加。吗啡一般在序列错误内增加，而不影响序列增加时的错误。
Rats lever pressed for food and learned new response sequences on 3 levers. At the beginning of each daily session, responses on only one of the levers produced food. After meeting criterion on one lever, the task was incremented so that sequential responses on 2 levers were required and so on up to 5 sequential responses. Each new required response was added in front of the previously performed sequence. Sequences of lever presses required to produce food changed each session. Following establishment of stable acquisition behavior, the acute effects of d-amphetamine (0.30-3.0 mg/kg), diazepam (0.125-4.0 mg/kg), morphine (0.30-10.0 mg/kg), pentobarbital (1.0-17.5 mg/kg) and chlorpromazine (0.10-3.0 mg/kg) were examined. All drugs decreased the number of response sequences completed in a dose-dependent fashion. Response rates generally decreased at or below those doses that caused an increase in errors. For d-amphetamine, the profound disruption of incremental repeated acquisition behavior was primarily due to drug-induced perserverative responding. Pentobarbital and chlorpromazine increased errors both when the sequence was incremented and within the sequence whereas diazepam only increased errors when the sequence was incremented. Morphine generally increased within sequence errors without affecting errors when the squence was incremented.