Ageing, tumour necrosis factor-alpha (TNF-α) and atherosclerosis
Ageing, tumour necrosis factor-alpha (TNF-α) and atherosclerosis
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DOI：
10.1046/j.1365-2249.2000.01281.x
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发表时间：
2000-08-01
影响因子：
4.6
通讯作者：
Pedersen, BK
中科院分区：
文献类型：
--
作者：
Bruunsgaard, H;Skinhoj, P;Pedersen, BK
衰老与血液中炎症活动的增加有关。本研究的目的是在一组130名81岁的人中调查年龄相关的TNF-α血浆水平升高是否与动脉粥样硬化相关。与年轻对照组（n = 44）相比，老年队列的TNF-α、C-反应蛋白（CRP）、总胆固醇（TC）、低密度脂蛋白（LDL）和低高密度脂蛋白（HDL）/TC比值的循环水平升高。老年组按三分位数分为三个亚组，分别为低、中和高水平TNF-α。在TNF-α浓度高的组中，临床诊断为动脉粥样硬化的比例显著更大。此外，一方面发现TNF-α与甘油三酯、白细胞、CRP和低HDL/TC比率的血液浓度之间存在弱相关性，而后者是已知的动脉粥样硬化形成和血栓栓塞并发症的风险因素。TNF-α、TC、LDL或体重指数之间没有相关性。总之，本研究表明，在81岁的人群中，血液中高水平的TNF-α与动脉粥样硬化的高患病率相关。
Ageing is associated with increased inflammatory activity in the blood. The purpose of this study was to investigate if age-related increased plasma levels of TNF-alpha were associated with atherosclerosis in a cohort of 130 humans aged 81 years. The elderly cohort had increased circulating levels of TNF-alpha, C-reactive protein (CRP), total cholesterol (TC), low-density lipoproteins (LDL) and a low high-density lipoprotein (HDL)/TC ratio compared with a young control group (n = 44). The elderly cohort was divided by tertiles into three subgroups with low, intermediate, and high levels of TNF-alpha, respectively. In the group with high TNF-alpha concentrations a significantly larger proportion had clinical diagnoses of atherosclerosis. Furthermore, weak correlations were found between TNF-alpha on one hand and blood concentrations of triglycerides, leucocytes, CRP and a low HDL/TC ratio on the other which are known as risk factors of atherogenesis and thromboembolic complications. No correlations were found between TNF-alpha, TC, LDL, or the body mass index. In conclusion, the present study shows that in a cohort of 81-year-old humans, high levels of TNF-alpha in the blood were associated with a high prevalence of atherosclerosis.